Antimicrobial Pharmacology session 1 Flashcards
Prontosil is against which organisms?
strep and staph
What does Prontosil make in the body?
sulfonamide
What sulfonamide does?
prevent the synthesis of folic acid in bacteries
What do we use for chronic prostatitis?
fluoroquinolone
Optimum concentration
4 times more than the standard amount
MIC
minimum inhibitory concentration
MBC
minimum bactericidal concentration
strip or targigi?
strip is better because the amounts are closer and the results are better
معیار اصلی در دسته بندی آنتی بیوتیک ها
ساختاری که دارو در باکتری به آن اثر می گذارد
Antibiotics that affect the folic acid synthesis
trimethoprim
sulfonamide
Antibiotics that affect 50S protein synthesis
erythromycin
chloramphenicol
clindamycin
Antibiotics that affect 30S protein synthesis
tetracycline spectinomycin streptomycin gentamycin tobramycin amikacin aminoglycosides
Antibiotics that affect DNA and RNA
quinolone
rifampin
drugs that avoid cell wall synthesis are?
bactericide
vancomycin is?
glycopeptide
Telavancin is made up of?
vancomycin
Dalbavancin is made up of?
teicoplanin
Colistin
has lots of side effects but is used for some severe cases
Cell-membrane related drugs
daptomycin and polymyxin
aplastic anemia
chloramphenicol
جایگزینی به جای تتراسایکلین در باردارها
chloramphenicol
دارویی با طیف گسترده و باکترواستاتیک
Tetracycline
دارویی با طف گسترده و باکتریوساید
Carbapenem
Clindamycin is effective on?
gram-positive non-O2
Drugs in the group of macrolides
erythromycin
clarithromycin
azithromycin
spiramycin
anti-inflammation effects?
azithromycin
To treat toxoplasmosis in pregnancy
spiramycin
To treat helicobacter pylori
clarithromycin
Aminoglycosides are effective on?
gram-negative and O2
how can we use aminoglycosides for gram positives?
with B-lactams
سوزاک؟
spectinomycin (only used for these cases)
The main treatment of Gonorrhea?
B-lactams but for replacement, we use spectinomycin
Streptogramins?
quinupristin and dalfopristin
Treatment of penicillin-resistant streptococci pneumonia & vancomycin-resistant staph
Linezolid
Protein synthesis inhibitor but uses tRna
Mupirocin
Drugs that affect nucleic acids
rifamycin
fluoroquinolone
rifaximin
fidaxomicin
موثر بر سل و جذام و عفونت شدید استاف و درمان مننژیت و بروسلوز؟
Rifampin
Treatment of chronic prostatitis
fluoroquinolone
درمان اسهال مسافرتی
rifaximin
در روده به مدت طولانی باقی می ماند
Antimetabolites
sulfonamide (bacteriostatic) trimethoprim pyrimethamine proguanil methotrexate
To treat toxoplasma ghondi
sulfadiazine with pyrimethamine
Only effective on human reductase
Methotrexate
Metronidazole
non-O2 and single cells
Reasons we use antibiotics
prophylaxis
treat
Empirical
give drugs for a variety of infections
definitive
give drug for specific type of infection
درمان پنومونی اکتسابی از جامعه
levofloxacin
درمان پیلونفریت
ceftriaxone