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Pharmacology > Antimicrobial Pharmacology Session 4 > Flashcards

Antimicrobial Pharmacology Session 4 Flashcards

1
Q

Aminoglycosides

A 
Streptomycin
Neomycin
Kanamycin
Paromomycin
Tobramycin
Gentamicin
Amikacin
Spectibomycin
Netilmicin
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2
Q

خط اول دفاعی در برابر سل

A

Streptomycin

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3
Q

درمان‌های موثر بر سل

A

Streptomycin + kanamycin

Imipenem + clavulanic acid

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4
Q

Alternative for ceftriaxone for گونوکوک

A

Spectinomycin

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5
Q

طیف اثر آمینوگلیکوزید

A

موثر بر گرم‌منفی‌های هوازی

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6
Q

Synergistic relation between?

A

Aminoglycosides and antibiotics

Vancomycin and penicillin

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7
Q

Aminoglycosides mechanisms to inhibit protein synthesise

A

Block protein synthesise
مهار تداوم پروتئین سازی
Miscoding

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8
Q

Which drug doesn’t have miscoding?

A

Spectinomycin

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9
Q

Resistance to aminoglycosides mechanisms?

A

Inactivation of enzymes
Decrease diffusion of antibiotics
تغییر تمایل اتصال

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10
Q

Full cross resistance

A

Kanamycin & neomycin

Netilmicin, kanamycin, tobramycin, gentamicin, amikacin

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11
Q

Diffusion problems of aminoglycosides

A

Diffuse to kidney and has nephrotoxicity

Diffuse to endolymph and perilymph

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12
Q

2 important features of aminoglycosides

A

Post-antibiotical

Amount related

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13
Q

Patients that cannot use single dose aminoglycosides

A

Pregnants
Kidney injury
Infants
Endocarditis

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14
Q

استریل روده قبل جراحی

A

Neomycin

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15
Q

پیشگیری از کمای هپاتیک یا انسفالوپاتی کبدی

A

Neomycin

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16
Q

درمان آمیبیازیس

A

Paromomycin

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17
Q

عفونت‌های جلدی ناشی از گرم منفی

A

‌neomycin

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18
Q

لشمانیوز احشایی

A

Paromomycin تزریقی

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19
Q

لشمانیوز پوستی و تریکوموناس

A

Paromomycin موضعی

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20
Q

ژیاردیازیس‌های دوره بارداری

A

استفاده از paromomycin خوراکی به جای metronidazole

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21
Q

تولارمی یا تب خرگوشی

A

Gentamicin and streptomycin

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22
Q

طاعون

A

Streptomycin & tetracycline

23
Q

سودوموناس (پنومونی یا باکتریمی)

A

Broad spectrum penicillin
+
Tobramycin and cefdazidim

24
Q

برسلوز یا تب مالت

A

Doxycycline and gentamicin

Doxycycline and rifampin

25
Q

اتدوکاردیت و باکتریمی استرپتوکوکی

A

Gentamicin + penicillin G

26
Q

Treatment of enteroco

A

Ampicillin OR penicillin G
Both with gentamicin

Or vancomycin + gentamicin
[Vancomycin allergic]

Linezolid and quinupristin-dalfopristine
[Vancomycin resistant]

27
Q

درمان گنوره

A

Spectinomycin

28
Q

Highest and lowest kidney injury causes of aminoglycosides

A

Neomycin

Streptomycin

29
Q

آسیب شنوایی

آسیب تعادلی

A

Amikacin and kanamycin

Gentamicin and streptomycin

30
Q

Contraceptions aminoglycosides

A

B-lactam and aminoglycosides

Diuretic and hearing

Warfarin and خونریزی

آمینوگلیکوزید در دوران شیردهی

آمینوگلیکوزید در دوران بارداری

31
Q

Groups of tetracyclines

A

Natural: demeclocycline and tetracycline
Semisynthetic: doxycycline

32
Q

Treatment of unusual secretion of ADH

A

Demeclocycline

Lithium carbonate

33
Q

Treatment of H. Pylori

A

Tetracycline

+chloromycetin

34
Q

Resistance mechanisms to tetracycline

A

Decrease accumulation of tetracycline
Decrease approach to tetracycline
Enzymatic inactivation

35
Q

We can’t use tetracyclines with?

A

دو یا سه ظرفیتی‌ها

36
Q

حساس به شیر و دوغ

A

Tetracycline

37
Q

Tetracyclines are mostly found in?

A

High calcium turnover

Liver

38
Q

درمان تب مالت

A

Long use of doxycycline (2-3 months)

39
Q

Disposal of minoxycline and doxycycline

A

Liver

40
Q

درمان آکنه‌های مقاوم به درمان موضعی

A

Tetracycline

41
Q

درمان وبا در زیر ۸ سال

A

Tetracycline ❌️

Azitromycin

42
Q

Treatment of ricketssia

A

Doxycycline

If not: chloramphenicol

43
Q

عامل و درمان بیماری لایم

A

بورلیا

Doxycycline

44
Q

Alternative drugs for macrolides

A

Doxycyclines

45
Q

Treatment for leptospira and treponema

A

B-lactams

Alternative: doxycycline

46
Q

Treatment for borrelia

A

Doxycycline

Alternative: B-lactams

47
Q

آلترناتیو درمان سیفیلیس حساس به پنی‌سیلین

A

Doxycycline

48
Q

درمان ترشح نامناسب ADH

A

Demeclocycline and lithium carbonate

49
Q

Contraindications of tetracycline

A 
دو یا سه ظرفیتی‌ها
Cholestyramine (inhibits cholesterol)
Sucralfate (aluminium) 
پنی‌سیلین
OCPs
Digoxin
Alcohol
Warfarin
50
Q

ضد تشنج‌ها

A

Phenobarbital

Phenytoin

51
Q

Side effects of tetracyclines

A 
تهوع
استفراغ
اسهال
بی‌اشتهایی
زخم مری
فوبیای نور
دیابت نفروژنیک
ندروم شبه فانکونی
52
Q

داروی درمانی در عفونت‌های داخل شکمی

A

Tigecycline

53
Q

Most common side effect of tygecycline

A

تهوع و استفراغ

Pharmacology (9 decks)

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