Antimicrobial Pearls

Question 1

Which penicillin may be used to treat pseudomonas infections?

Answer 1

Piperacillin/Tazobactam

Question 2

Cefazolin + Cephalexin generation

Answer 2

First Generation Cephalosporins

Question 3

Cefuroxime and Cefoxitin Generation

Answer 3

Second Generation Cephalosporins

Question 4

Ceftriaxone, Ceftazidime Generation

Answer 4

Third Generation Cephalosporins

Question 5

Cefepime Generation

Answer 5

Fourth Generation Cephalosporin

Question 6

Ceftaroline Generation

Answer 6

Fifth Generation Cephalosporin

Question 7

2nd Gen cephalosporing w/ gram negative anaerobe coverage.

Answer 7

Cefoxitin

Question 8

Which cephalosporins have psuedomonas coverage?

Answer 8

1. Ceftazidime
2. Cefepime

Question 9

Which cephalosporin has MRSA coverage?

Answer 9

Ceftaroline

Question 10

Which carbapenem does not cover Pseudomonas?

Answer 10

Ertupenem

Question 11

Aminoglycoside Pseudomonas Hierarchy

Answer 11

Amikacin > Tobramycin > Gentimicin

Question 12

Atypical Coverage

Answer 12

Tetracyclines
Macrolides
Fluoroquinolones

Question 13

_____ has excellent bone penetration.

Answer 13

Lincosamides

Question 14

Macrolide Gram Positive vs Negative Aerobe Heirarchy

Answer 14

Positive: Erythromycin > Clarithromycin > Azithromycin
Negative: A > C > E

Question 15

Who are fluoroquinolones not recommended in?

Answer 15

<18 yo
Pregnancy

Question 16

Drug of Choice for MRSA

Answer 16

Vancomycin

Question 17

_____ should not be used for pneumonia due to surfactant inhibition.

Answer 17

Daptomycin

Question 18

____ is associated with skeletal myopathy.

Answer 18

Daptomycin

Question 19

____ may interfere with coagulation tests.

Answer 19

Telvancin.

Question 20

______ is very good for pneumocystitis carinni

Answer 20

Bactrim.

Question 21

____ is great for anaerobes and is associated with disulfiram reactions.

Answer 21

Metronidazole.

Question 22

_____ is associated with serotonin syndrome and peripheral neuropathy with long-term use.

Answer 22

Linezolid. (Oxazolidinones.)

Question 23

MRSA Coverage Agents

Answer 23

Ceftaroline
Lincosamides (moderate)
Fluoroquinolones (poor)
Vancomycin (DOC)
Daptomycin
Telavancin
Bactrim (good)
Linezolid (second line)