antimicrobial modes of actions and mechanisms of resistance Flashcards
1
Q
what are the requirements for antimicrobial activity?
A
Adsorption to cell surface
passage into cell
interaction with target
2
Q
what are the three mechanisms of killing the microbes?
A
Oxidation
X linking
Coagulation
3
Q
what are the mechanisms of resistance
A
intrinsic or innate: a natural chromosomally encoded property
Extrinsic or acquired: organisms become resistant
4
Q
what is co resistance
A
the plasmid carries multiple resistance genes.
5
Q
Hierarchy of intrinsic resistance?
A
prions are very resistance Bacterial spores Mycobacteria small non enveloped viruses Gram negative Fungi large non enveloped bacteria Gram positive Lipid enveloped viruses
