antilipemic drugs (broadhead)

Question 1

HMG-Co Reductase inhibitors

Answer 1

statins

Question 2

prototype name for statins

Answer 2

simvastatin (Zocor), atorvastatin (Lipitor)

Question 3

action of statins

Answer 3

reduce ldl and vldl, increase HDL recommended to reduce mortality in clients with type 2 diabetes

Question 4

indications of statins

Answer 4

support the treatment of coronary heart disease, antilipemics

Question 5

side effect of statins

Answer 5

myopathy

Question 6

adverse reactions of statins

Answer 6

rhabdomylosis causing kidney damage, liver toxicity

Question 7

contraindications of statins

Answer 7

pregnency category X, current liver disease, renal failure, MS, myopathy, children

Question 8

special considerations of statins

Answer 8

monitor myopathy, measure CPK id musclle pain occures, monitor LFTs, take in the evening

Question 9

prototype name for fibrates

Answer 9

gemfibrozil (Lopid)

Question 10

action of gemfibrozil

Answer 10

decrease vldl and increase hdl

Question 11

indications of gembibrozil

Answer 11

reduces high levels of plasma TG, reduces ldl cholesterol (less effective than statins)

Question 12

side effects of gemfibrozil

Answer 12

nausea, vomiting, diarrhea, gallstones, myopathy

Question 13

adverse effects of gemfibrozil

Answer 13

liver toxicity

Question 14

contraindications of gemfibrozil

Answer 14

gallbladder disease, liver dysfunction, severe renal impairment

Question 15

special considerations of gemfibrozil

Answer 15

monitor for GI symptoms, monitor for myopathy, measure CPK if myopathy occurs, monitor LFTs