Antihyperlipidemic Drugs Flashcards
1
Q
cholestyramine
A
- hypercholesterolemia
- MOA: binds bile acids increasing production of bile acids from cholesterol, decreases LDL
- side effects: constipation, abdominal discomfort, pancreatitis, bloating
2
Q
niacin
A
- hypertriglyceridemia
- MOA: poorly understood, decreases VLDl, increases HDL
- side effects: vasodilation, flushing, hepatotoxicity, hyperglycemia, hyperuricemia
3
Q
gemfibrozil, fenofibrate
A
- hypertriglyceridemia, mild effect to increase HDL and decrease LDL
- MOA: activate PPAR-alpha and increase lipoprotein lipase (LPL) and decrease TGs
- side effects: rhabdomyolysis (esp if gemfibrozil given with statin) increased LFTs, gallstones
4
Q
statins
A
- lovastatin, simvastatin, pravastatin, atorvastatin, rosuvastatin
- hypercholesteremia
- MOA: HMG co-A reductase inhibitor, decrease LDL
- side effects: muscle aches, rhabdomyolysis, hepatitis
5
Q
evolocumab, alirocumab
A
- hypercholesteremia
- MOA: antibodies that block effect of PCSK9 to break down LDL receptors
- side effects: memory problems?
