Antigout

Question 1

antigout meds

Answer 1

• colchicine

- allopurinol (uricosuric agent)

Question 2

colchicine moa

Answer 2

• inhibits wbc into body tissue containing urate crystals

- decreases inflammatory reaction to urate crystals in tissue

Question 3

colchicine indications

Answer 3

treatment and prophylaxis of acute gout in adults

Question 4

colchicine ae

Answer 4

• gi: n/v, dyspepsia, abdominal pain
• heme: possible bone marrow supression
• hepatotoxicty
• peripheral neuropathy

Question 5

colchicine implications

Answer 5

• admin with food
• assess for vomit and diarrhea due to dehydration and f&e balance
• monitor for numbness in extremities

Question 6

colchicine teaching

Answer 6

• if have acute flare up, take 1 dose, 2nd dose in 1 hour
• report muscle weakness and severe diarrhea!!!
• low purine diet: avoid etoh, organ/game meats, spinach, peas, anchovies, asparagus

Question 7

allupurinol moa

Answer 7

• inhibits enzyme that changes purine to uric acid thus decreasing uric acid production
• decreases serum and urinary uric acid level
• decreases sx of gout

Question 8

allupurinol ae

Answer 8

• cns: drowsiness, ha, vertigo
• heme: agranulocytosis, bone marrow suppression
• gi: n/v, diarrhea, abdominal pain, indigestion

Question 9

allopurinol implications

Answer 9

• drink lots of fluids
• admin after meals for absorption
• assess cloudy urine
• assess gi effects
• monitor for bleeding, bruising, anemia
• monitor lft, cr clearance

Question 10

allopurinol education

Answer 10

• increased fluid 3-4L a day
• call hcp if decreased uo and cloudy urine
• maintain appointments for uric acid levels, liver enzymes, cr clearance to be drawn