Antifungals Flashcards
1
Q
drug used for superficial mycoses
A
clotrimazole/lotrimin topical
2
Q
amphotericin B
A
gold standard systemic antifungal
broad spectrum
used for life threatening infections
toxicity
3
Q
amphotericin B MOA
A
binds ergosterol in fungal cell membrane forming pores which lead to increased permeability and cell death
4
Q
azole antifungals
A
flucanoazole, etc
inhibit CYP450
block formation of ergosterol - static
5
Q
most used systemic antifungal
A
fluconazole
6
Q
fluconazole
A
lacks toxicity
good oral bioavailability
active against c albicans
limited spectrum
7
Q
echinocandins
A
caspofungin, micafungin, etc MOA: cause disruption of fungal cell wall causing cell death IV only well tolerated and few interactions limited spectrum
8
Q
indications for nystatin
A
topical
ring worm, tinea pedis, tinea cruris, oral candidiasis, vaginal candidiasis
9
Q
what is used for dermatophyt/nail infections
A
Terbinafine - interferes with ergosterol biosynthesis
