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Microbiology > Antifungals > Flashcards

Antifungals Flashcards

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Biology 101 flashcards
1
Q

Antifungal drugs target:

a. Ergosterol synthesis
b. Cell wall synthesis
c. Cell division
d. Nucleic acid synthesis
e. All of the above

A

e. All of the above

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2
Q

T/F Ergosterol is a vital part of the cell membranes of fungi but not found in the cell membranes of humans

A

T

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3
Q

Drugs targeting Ergosterol include:

a. Polyenes
b. Azoles
c. Allylamines
d. All of the above

A

d. All of the above

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4
Q

Amphotericin B is the drug of choice for most systemic fungal infections because it:

a. Binds ergosterol
b. inhibits B-1,3 glucan synthesis
c. inhibits fungal protein synthesis
d. all of the above

A

a. Binds ergosterol

Polyene

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5
Q

Nyastatin is used to treat oral & esophageal infections along with vaginal candidiasis because it:

a. Binds ergosterol
b. inhibits B-1,3 glucan synthesis
c. inhibits fungal protein synthesis
d. all of the above

A

a. Binds ergosterol

Polyene

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6
Q

Amphotericin B is known to have which of these adverse side effects?

a. Renal toxicity
b. chills & fever
c. phlebitis (inflammation of vein)
d. all of the above

A

d. all of the above

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7
Q

Azoles are:

a. chemically synthesized drugs that inhibit cytochrom P450 14a-demtheylase
b. inhibits B-1,3 glucan synthesis
c. inhibits fungal protein synthesis
d. all of the above

A

a. chemically synthesized drugs that inhibit cytochrom P450 14a-demtheylase

ergesterol

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8
Q

Ketoconazol is used for:

a. chronic mucocutaneous candidiasis
b. Karenia brevis
c. your mom
d. all of the above

A

a. chronic mucocutaneous candidiasis

Imidazole
ergesterol

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9
Q

Miconazole and Clotrimazole are used to treat:

a. cutaneous candidiasis
b. tinea versicolar
c. dermatophytosis
d. all of the above

A

d. all of the above

Imidazole
ergesterol

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10
Q

Fluconazole is used to treat:

a. cutaneous candidiasis
b. vaginal candidiasis
c. cryptomeningitis
d. all of the above

A

d. all of the above

Triazole
ergesterol

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11
Q

Itraconazole is used to treat:

a. chromoblastomycosis
b. histoplasmosis
c. coccidiomycosis
d. all of the above

A

d. all of the above

Triazole
ergesterol

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12
Q

Posaconazole is used to treat:

a. candida
b. aspergillus
c. none of the above
d. both a & b

A

d. both a & b

Triazole
ergesterol

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13
Q

Naftifine is an_____ and is used to treat_____

a. allyamine; dermatophyte infections
b. azole; dermatophyte infections
c. polyene; dermatophyte infections
d. none of the above

A

a. allyamine; dermatophyte infections

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14
Q

terbinafine is an_____ and is used to treat_____

a. allyamine; dermatophyte infections
b. azole; dermatophyte infections
c. polyene; dermatophyte infections
d. none of the above

A

a. allyamine; dermatophyte infections

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15
Q

Caspofungin, an Echinocandin is used to treat Candida & Aspergillus because it:

a. chemically synthesizes drugs that inhibit cytochrom P450 14a-demtheylase
b. inhibits B-1,3 glucan synthesis
c. inhibits fungal protein synthesis
d. all of the above

A

b. inhibits B-1,3 glucan synthesis

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16
Q

Griseofulvin (oral) targets____ and is active against____.

a. cell division; ringworm of skin, nails, or hair
b. ergesterol; ringworm of skin, nails, or hair
c. nucleic acid synthesis; ringworm of skin, nails, or hair
d. none of the above

A

a. cell division; ringworm of skin, nails, or hair

17
Q

Flucytosine is effective against candidiasis & cryptococcosis (used syn w/amphotericin B) because it:

a. chemically synthesizes drugs that inhibit cytochrom P450 14a-demtheylase
b. inhibits B-1,3 glucan synthesis
c. inhibits fungal protein synthesis
d. all of the above

A

c. inhibits fungal protein synthesis

replaces uracil w/ 5-flurouracil in fungal RNA

18
Q

Metronidazole is activated by anaerobic metabolism, interferes with electron transport & alters DNA. It is used to treat:

a. Entamoeba histolytica
b.Giardia lambia
c. Trichomonas vaginalis
d. all of the above

A

d. all of the above

19
Q

Chloroquine prevents crystallization of heme in RBC; thus, it is active against:

a. Plasmodium vivax
b. Plasmodium ovale
c. Plasmodium malariae
d. Plasmodium falciparum
e. all of the above

A

e. all of the above

Erythrocytic cycle (acute malaria)

20
Q

Amodiaquine is active against

a. Plasmodium vivax
b. Plasmodium ovale
c. Plasmodium malariae
d. Plasmodium falciparum
e. all of the above

A

e. all of the above

except chloroquine-resistant P.falciparum
Erythrocytic cycle (acute malaria)

21
Q

T/F Mefloquine is the most effective erythrocytic cycle anti-malarial drug and is effective as prophylaxis.

A

T

22
Q

Primaquine-Sulfadoxine is used to treat:

a. chloroquine-resistant P.falciparum
b. Plasmodium vivax
c. Plasmodium ovale
d. all of the above

A

d. all of the above

Exo-erythrocytic cycle (persistent malaria)

23
Q

T/F Artimisinin generates free radicals w/in parasite that damage membrane

A

T

24
Q

Suramin and Melarsoprol can be used to treat:

a. Trypanosomia cruzi
b. Trypanosomia brucei
c. Exophiala werneckii
d. all of the above

A

b. Trypanosomia brucei

25
Q

Nifurtimox and Benzonidaxole canbe used to treat:

a. Trypanosomia cruzi
b. Trypanosomia brucei
c. Exophiala werneckii
d. all of the above

A

a. Trypanosomia cruzi

26
Q

Mebendazole, thiabendazole, albendazole, Pyrantel pamoate, Piperazine are used to paralyze:

a. Ascaris lumbricoides
b. Necator americanus
c. Enterobius vermicularis
d. Trichuric trichiura
e. Strongyloides stercoralis
f. all of the above

A

f. all of the above

27
Q

T/F Algae do not directly infect humans

A

T

28
Q

chlorophytes are:

a. green algae
b. red algae
c. golden brown algae & diatomes
d. brown algae

A

a. green algae

29
Q

Rhodophyta are:

a. green algae
b. red algae
c. golden brown algae & diatomes
d. brown algae

A

b. red algae

30
Q

Chrysophyta are:

a. green algae
b. red algae
c. golden brown algae & diatomes
d. brown algae

A

c. golden brown algae & diatomes

31
Q

Phaeophyta are:

a. green algae
b. red algae
c. golden brown algae & diatomes
d. brown algae

A

d. brown algae

32
Q

Microscopic algae are propelled by:

a. cilia
b. flagella
c. free-floating
d. pseudopods
e. all of the above
f. only b & c

A

f. only b & c

33
Q

Macroscopic algae have which of these specialized structures:

a. blades
b. bladders
c. stipe
d. holdfast
e. all of the above
f. only a & b

A

e. all of the above

34
Q

Algae’s cell wall is mostly composed of cellulose and contains carrageen & agar. Their cell structures include:

a. nucleus
b. chloroplasts
c. mitochondria
d. all of the above
e. only a & b

A

d. all of the above

35
Q

Algae asexually reproduce by:

a. binary fission
b. fragmentation
c. meiosis
d. only a & b

A

d. only a & b

36
Q

Karenia brevis is responsible for:

a. algal blooms in Texas coast from Aug-Feb; and produces brevetoxin
b. algal blooms in East coast; and produces brevetoxin
c. algal blooms in Texas coast from Aug-Feb; and produces saxitoxin, gonyautoxins; “paralytic shellfish poisoning”
d. algal blooms in East coast; and produces saxitoxin, gonyautoxins; “paralytic shellfish poisoning”

A

a. algal blooms in Texas coast from Aug-Feb; and produces brevetoxin

37
Q

Gonyaulax species, specifically Alexandrium fundynese is responsible for:

a. algal blooms in Texas coast from Aug-Feb; and produces brevetoxin
b. algal blooms in East coast; and produces brevetoxin
c. algal blooms in Texas coast from Aug-Feb; and produces saxitoxin, gonyautoxins; “paralytic shellfish poisoning”
d. algal blooms in East coast; and produces saxitoxin, gonyautoxins; “paralytic shellfish poisoning”

A

d. algal blooms in East coast; and produces saxitoxin, gonyautoxins; “paralytic shellfish poisoning”

38
Q

Dimorphic fungi can exist as either:

a. Bacillus or coccus
b. Yeast or mold
c. Enveloped or naked
d. Gram positive or negative

A

b. Yeast or mold

Microbiology (10 decks)

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