Antifungal medications Flashcards
1
Q
Major classes of antifungal agents. (7)
A
Azoles
Allylamines
Polyens Echinocandins Griseofulvin Flucytosin Chitin synthase inhibitors
2
Q
Drugs that inhibit Ergosterol synthesis
A
Allylamines - Terbinafine: Inhibits Squalene epoxide snthesis.
Azoles: Inhibit conversion of Lanosterol to Ergosterol
3
Q
What are the Polyen drugs and their mechanism
A
Polyens bind to ergosterol and form pores in the cell membrane.
Amphotericin B
Nystatin
Liposomal Amphotericin B lowers the side effects of amphotericin B for systemic use and gives it better penetration but is expensive.
4
Q
Mechanism of the Echinocandin drugs
A
Inhibit Beta-glucan synthase. An integral part of the fungi cell wall.
5
Q
What is the name of the fungal mitosis inhibitor drug?
A
Griseofulvin
6
Q
What is the name of the fungal pyrimidine analog?
A
Flucytosin
