ANTIFUNGAL DRUGS Flashcards
what type og antifungal is clotrimazole?
an azole
broad spectrum
what is clotrimazoles moa?
inhibition of yeast 14-alpha demethylase which converts lanosterol to ergosterol = increased membrane permeability and possible disruption of membrane bound enzymes
what are the indications for clotrimazole?
vaginal candidiasis
fungal skin infections
fungal infection in otitis media
what is fluconazoles moa?
inhibition of 14-alpha demethylase which converts lanosterol to ergosterol = increased membrane permeability and possibly disruption of membrane bound enzymes
what are the indications for fluconazole?
vaginal and mucosal candidiasis
Tinea pedis, corporis, cruris, pityriasis versicolor,
Dermal candidiasis
invasive candidal infections
Prevention of fungal infections in immunocompromised patients
what tyoe if drug is nystatin/
a polyene antifungal agent
what is nystatins moa?
binding to ergosterol in fungal cell membranes which causes the formation of pores in the membrane leading to cellular constituents leaing out = cell death
what are the indications for nystatin?
oral candidiasis
oral and perioral fungal infections
what is amphoterecins moa?
bidning to ergosterol in fungal cell membranes = formation of pores = cellular constituent leakage = cell death
what are the 4 classes of anti-fungals?
polyenes
azoles
allylamines
echinocandins
how do polyenes work?
they bind to ergosterol in memvranes, forming pores. this reuslts in a loss of membrane selective permeability and cytoplasic components
whata re 2 examples of poleyenes?
nystatin and amphotericin B
what is the moa of azoles?
inhibition of lanosterol demethylase which results in the depletion of ergosterol
what are examples of azoles?
ketaconazole
clotrimazole
econazole
what is the moa of allylamines?
inhibition of squalene epoxidase which converts squalene to ergosterol
this leads to squalene accumulation intracellularyl which is toxic = rapid cell death
