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Orgmed > Antifungal Agents > Flashcards

Antifungal Agents Flashcards

1
Q

All fatty acids and their salts have fungicidal properties

A

FATTY ACIDS

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2
Q

Only topically, Inhibits androgen and adrenal steroid synthesis

A

Ketoconazole

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3
Q

Adverse Effect of Ketoconazole

A

gynecomastia

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4
Q

present in perspiration (0.01%)

A

Propionic Acid

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5
Q

from caprylic acid (in coconut and palm oil)

A

Sodium Caprylate

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6
Q

from destructive distillation of castor oil

A

Undecylenic Acid

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7
Q

Lacks the endocrinologic effects of ketoconazole

A

Itraconazole

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8
Q

inhibits squalene epoxidase

A

Terbinafine

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9
Q

Absorption is increased with fatty acids

A

GRISEOFULVIN (Penicillum griseofulvum)

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10
Q

Excellent penetrability into the CSF

A

Fluconazole (PO, IV)

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11
Q

DOC for cryptococcal meningitis

A

Fluconazole (PO, IV)

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12
Q

DOC for systemic mycoses

A

Amphotericin B

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13
Q

Mechanism of Action of GRISEOFULVIN (Penicillum griseofulvum)

A

Interacts with the microtubule within the fungus and inhibit mitosis (metaphase)

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14
Q

Mechanism of Action of AZOLES

A

interacts with C 14 α demethylase to block demethylation of lanosterol to ergosterol in membranes

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15
Q

Mechanism of Action of POLYENES

A

Pore formation; binds to ergosterol—>disrupts membrane function—>cell death

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16
Q

Candida infections

A

Nystatin

17
Q

(Streptomyces natalensis)

A

Natamycin

18
Q

(Streptomyces noursei)

A

Nystatin

19
Q

(Streptomyces nodosus)

A

Amphotericin B

20
Q

pyrimidine, + Amphotericin B

A

Flucytosine

21
Q

(systemic mycoses & meningitis Cryptococcus & Candida)

A

Amphotericin B

22
Q

Mechanism of Action of NUCLEOSIDES

A

Inhibits DNA and RNA synthesis

23
Q

For superficial mycoses

A

Clotrimazole, Miconazole, Econazole

24
Q

For SC and systemic mycoses

A

Ketoconazole, Itraconazole, Fluconazole

Orgmed (10 decks)

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