Anthelminthics Flashcards
Drugs under Nematodes
Albendazole, Mebendazole (Antiox ®), Pyrantel Pamoate, Piperazine, Ivermectin, Thiabendazole, Diethylcarbamazine
Drugs under Trematodes
Praziquantel
Drugs under Cestodes
Niclosamide
Inhibits microtubule synthesis
Albendazole
Inhibits microtubule synthesis, Depletes glucose
Mebendazole (Antiox ®)
Depolarizing neuromuscular agent (nicotinic receptors)
Pyrantel Pamoate
Flaccid paralysis of helminth (Blocks Ach response)
Piperazine
Targets GABA receptors—> paralysis
Ivermectin
Also affects microtubular aggregation
Thiabendazole
Increases membrane permeability to calcium—>
contraction—>vacuolization—>parasite death
Praziquantel
inhibits oxidative phosphorylation
Niclosamide
Adverse effects of Thiabendazole
Erythema multiforme and SJS (fatal)
Albendazole, Mebendazole (Antiox ®), Pyrantel Pamoate, Piperazine, Ivermectin, Thiabendazole, Diethylcarbamazine
Roundworm (intestinal and muscle), Hookworms (old and new), Whipworm, Pinworm
Onchocerca volvulus (river blindness)
Ivermectin
Strongyloidiasis (threadworm)
Thiabendazole