Antiemetics

Question 1

what is CINV

Answer 1

chemotherapy induced nausea and vomiting

Question 2

this medication is used to treat viral gastritis, morning sickness, nausea caused from anesthia, and pretreatment for cancer patients

Answer 2

ondansetron (Zofran)

Question 3

prolonged QT interval, headache, diarrhea, dizziness are adverse effects for this medication

Answer 3

ondansetron (Zofran)

a prolonged QT interval can cause a dysrhythmia

Question 4

this medication blocks the type 3 serotonin receptors on the afferent vagal nerve

Answer 4

ondansetron (Zofran)

Question 5

prochlorperazine (Compazine) and metoclopramide (Reglan) belong to this drug classifcation

Answer 5

dopamine antagonists

Question 6

these drugs block the dopamine-2 receptors in the chemoreceptor trigger zone

Answer 6

prochlorperazine (Compazine) and metoclopramide (Reglan)

Question 7

Adverse effects of prochlorperazine (Compazine)

Answer 7

extrapyramidal reactions, anticholineric effects, hypotension, and sedation

Question 8

routes of administration for ondanserton/zofran

Answer 8

sublingual, intravenous, oral, or intramuscular

the 1st two are the most common

Question 9

aprepitant (Emend) is from this drug class

Answer 9

substance P neurokinin-1 antagonists

Question 10

this drug blocks the neurokinin-1 type receptors in the chemoreceptor trigger zone (CTZ)

Answer 10

aprepitant (Emend)

Question 11

this antiemetic drug can causes tardiave dyskinesia

Answer 11

metoclopramide (Reglan)

Question 12

extrapyramidal reactions are

Answer 12

involuntary muscle movements

acute dyskinesias, dystonic reactions, tardive dyskinesia, parkinsonism, akinesia, akathisa, and neuroleptic malignant syndrome

Question 13

anticholineric effects are

Answer 13

dry mouth, constipation, urinary retention, dilated pupils, increase in heart rate, and decreased sweating