Antidysrhythmic, cholesterol, angina drugs Flashcards
Classes of antidysrhythmic drugs
Class Ia, Ib, Ic - sodium channel blockers
Class II - Beta blockers
Class III - potassium channel blockers
Class IV - calcium channel blockers
All antidysrhythmic drugs can
worsen an existing dysrhythmia or cause a new one
Lidocaine route
IV only
Lidocain class
sodium channel blocker
Lidocaine use
ventricular dysrhythmias, sustained ventricular tachycardia
Lidocaine MOA
blocks sodium channels
- slowed conduction
Lidocaine adverse effects
CNS - drowsy, confusion, paresthesia
Tingling, burning
Lidocaine interactions
digoxin
Lidocaine implications
- equipment for resuscitation must be available
- reduce dose in patient with impaired liver or renal blood flow
Amiodarone class
potassium channel blocker
Amiodarone route
PO, IV
Amiodarone use
only approved for life threatening ventricular dysrhythmias
Amiodarone MOA
blocks cardiac potassium channels
- delay heart repol
- prolong QT interval
Amiodarone interactions
- grapefruit juice
- diuretics: dysrhythmias
- BB, CCBs: cause bradycardia
- increases levels of other drugs
Amiodarone adverse effects
- pulmonary toxicity (pneumonitis, pulm fibrosis)
- visual damage
- cardiotoxicity: bradycardia
- thyroid toxicity
- hepatotoxic
- photosensitivity
- teratogenic
- n/v, anorexia
Amiodarone implications
- long half life (25-110 days)
- monitor TSH, liver
- monitor for pulm toxicity (wheezing, tachypnea, crackles, SOB, cough)
Verapamil, Diltiazem class
calcium channel blockers
Verapamil, diltiazem use
atrial fibrillation, atrial flutter, SVT
Verapamil, diltiazem MOA
blocks cardiac calcium channels
Verapamil, diltiazem adverse effects
constipation, peripheral edema, bradycardia, AV block, hypotension, HF
Verapamil, diltiazem interactions
digoxin - elevates levels
combining with BB can cause bradycardia, AV block, HF
Verapamil, diltiazem implications
- monitor BP and HR w/BB
- monitor digoxin w/CCC
Propranolol Class
BB
Propranolol Use
atrial fibrillation, sinus tachycardia, SVT
Propranolol MOA
blocks actions of beta receptors
- decrease BP and CO
Propranolol adverse effects
heart block, worsen HF, sinus arrest, hypotension, bronchospasm
Propranolol implications
- monitor BP and HR w/BB
- caution asthmatic/COPD
- contraindicated w/ sinus bradycardia, high degree heart block, HF
Digoxin route
PO, IV
Digoxin Use
CHF, supraventricular dysrhythmias
Digoxin MOA
slows conduction time through AV node
Digoxin adverse effects
dysrhythmias, n/v, anorexia, abdomen discomfort, visual disturbances
Digoxin implications
monitor potassium while taking digoxin
