Antidiabetic drugs/drug classes

Question 1

MOA: Increases insulin release

Answer 1

sulfonylureas

Question 2

MOA: agonist at PPARy receptors

Answer 2

TZDs - pioglitazone, rosigltizone

Question 3

MOA: decreases hepatic gluconeogenesis

Answer 3

metformin

Question 4

MOA: increases insulin sensitivity

Answer 4

TZDs - pioglitazone, rosigltizone

Question 5

MOA: increases activity life of endogenous GLP1 by inhibiting the metabolic enzyme

Answer 5

DPP4-i

Question 6

MOA: increases glucose-dependent insulin repease, slows gastric emptying, improves satiety

Answer 6

GLP1 agonists

Question 7

MOA: increases loss of glucose in urine

Answer 7

SGLT2 i

Question 8

Recommended 1st line treatment for T2DM

Answer 8

metformin

Question 9

Class of antidiabetic drugs that commonly causes hypoglycemia

Answer 9

sulfonylureas, insulin

Question 10

lactic acidosis is a rare but serious side effect

Answer 10

metformin

Question 11

antidiabetic that may cause edema or fluid retention

Answer 11

TZDs - pioglitazone, rosigltizone

Question 12

Should be stopped for at least 48 hours following IV contrast

Answer 12

metformin

Question 13

Classes of antidiabetic drugs that may help with weight loss

Answer 13

metformin
GLP1i
SGLT2i

Question 14

Classes of antidiabetic drugs that may cause weight gain

Answer 14

sulfonylurea - glipizide, glimepride
TZDs - pioglitazone, rosigltizone
insulin