Antidepressants

Question 1

SSRI

Answer 1

1st line tx

more 5HT available in synaptic gap

Question 2

SSRI meds

Answer 2

citalopram (Celexa)
escitalopram (Lexapro)
fluoxetine (Prozac)
paroxetine (Paxil)
sertraline (Zoloft)
fluvoxamine (Luvox)

Question 3

common s/e of SSRI

Answer 3

nausea
weight gain
insomnia
restlessness
agitation
dizziness
sexual dysfunction: ED, anorgasmia, decreased libido
suicidal ideations

Question 4

onset of SSRI

Answer 4

delayed!

3–4 wks

Question 5

TCA

Answer 5

tricyclic antidepressants
2nd line tx
blocks reuptake of 5HT and NE
blocks muscarinic and histamine receptors

Question 6

TCA meds

Answer 6

amitiptyline (Elavil)
amoxapine (Asendin)
doxepin (Sinequan)
imipramine (Tofranil)
desipramine (Norpramine)
nortriptyline

Question 7

TCA s/e

Answer 7

anticholinergic: blurred vision, urinary retention, dry mouth, constipation
orthostatic hypotension
can cause cardiac toxicity

Question 8

MAOI

Answer 8

3rd line tx
increases levels of NE, D2, and 5HT
used for tx resistant depression

Question 9

MAOI meds

Answer 9

isocarboxazid (Marplan)
phenelzine (Nardil)
tranicypromine (Parnate)

Question 10

MAOI s/e

Answer 10

lots of interactions with other drugs

must have low tyramine diet- can cause hypertensive crisis

Question 11

tyramine containing foods

Answer 11

fermented foods, beer, wine, aged cheese, soy sauce, sausages, pickled foods.