Antidepressants

Question 1

What Antidepressant categories deal with reuptake of neurotransmitters?

Answer 1

SSRIs
SNRIs
TCAs

Question 2

What antidepressant category deals with the breakdown of Neurotransmitters?

Answer 2

MAOIs

Question 3

What is the main limitation of the monoamine hypothesis?

Answer 3

Antidepressants act rapidly at the site of action…yet the clinical effects are not sen for about 3 weeks.

Question 4

What could be the possible reason for the 3 week delay from treatment to relief?

Answer 4

Presynaptic autoreceptors. They have an inhibitory signal to neurotransmitter production/release because they think there is too much postsynaptic NT….After weeks the signal is reduced and the treatment takes effect.

Question 5

SSRIs

Answer 5

Fluoxetine
Paroxetine
Sertraline
Citalopram
Escitalopram
Fluvoxamine

Question 6

Uses of SSRI’s

Answer 6

MDD, GAD, OCD, PTSD, PMDD, Bulimia

Question 7

SNRIs

Answer 7

Venlafaxine

Duloxetine

Question 8

SNRI Uses

Answer 8

MDD, Chronic Pain, Fibromyalgia, Menopause

Question 9

TCAs

Answer 9

Imipramine
Amitriptyline
Clomipramine
Desipramine
Nortiptyline

Question 10

TCA uses

Answer 10

MDD, Chronic Pain, OCD

Question 11

MAOIs and uses

Answer 11

Phenelzine
Tranylcypromine

MDD unresponsive to other drugs

Question 12

Serotonin Receptor Antagonists

Answer 12

Nefazodone

Trazodone

Question 13

Heterocyclics

Answer 13

Bupropion (smoking Cessation and MDD)

Mirtazapine (sedation and MDD)

Question 14

Lithium

Answer 14

Used to treat Bipolar Affective Disorder