ANTIDEPRESSANT AND MOOD STABILIZERS Flashcards

1
Q

Major depressive disorder

A

Depression

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2
Q

A mood disorder that causes a persistent feeling of sadness and loss of interest

A

Depression

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3
Q

Depression is the most common mental health disorder of elderly adults, encompassing a variety of

A

physical, emotional, cognitive and social considerations

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4
Q
  • Lack of energy, extremely tired
  • Abnormal eating patterns, feeling of despair
    -Guiltiness and hopelessness and misery
  • Sleep disturbance like difficulty sleeping or too much sleep
  • Vague physical symptoms (Gl pain, joint/muscles pains or headaches)
  • Obsessed with death (expressing a wish to die or to commit suicide)
  • Lack of interest in personal appearance or sex Delusion or hallucinations
A

S/Sx associated w/ depression

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5
Q

Sudden onset after the precipitating event

A

Reactive depression

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6
Q

Sometimes called manic depression, has mood episodes that range from extreme of high energy with an “up” mood to low “depressive” periods. Swings between two moods - euphoric and dysphoric

A

Bipolar disorder

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7
Q

Loss of interest to work and even at home and inability to complete tasks. Difficult to study, sleep, eat and enjoy friends and activities

A

Major depression

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8
Q

help clients gain insight into and resolves their problems through verbal “give - and - take” with the therapy’s Interpersonal therapies

A

Counseling therapies

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9
Q

help the client change the negative styles of thought and behavior that are often associated with their depression

A

Cognitive behavioral therapies

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10
Q

focuses on the clients disturbed personal relationship that both cause and exacerbate the depression

A

Interpersonal therapies

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11
Q

focus on resolving the client’s internal conflicts

A

Psychodynamic therapies

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12
Q

A medical treatment for clients with serious and life-threatening mood disorders that are unresponsive to pharmacotherapy and often used treatment for depression that is hard to treat.

A

ELECTROCONVULSIVE THERAPY (ECT)

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13
Q

Effective somatic treatment for major depression

A

REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS)

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14
Q

Treat major depression by enhancing mood

A

ANTIDEPRESSANT

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15
Q

Antidepressant is often prescribe to

A

phobia, OCD, panic, and anxiety

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16
Q

Beneficial in treating psychological and physical signs of pain, especially in clients without major depressive disorder

A

Antidepressant

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17
Q

the most important warning about antidepressants. This should be included at the beginning of drug package inserts and drug information sheets. This warning to applies to children who are at risk for suicidal ideation.

A

Black box warning

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18
Q

WHAT ARE THE FOUR PRIMARY CLASSES OF ANTIDEPRESSANT DRUGS?

A
  1. Tricyclic antidepressants (TCAs)
  2. Selective serotonin reuptake inhibitors (SSRIs)
  3. Monoamine oxidase inhibitors (MAOIs)
  4. Atypical antidepressants including the serotonin norepinephrine reuptake inhibitors (SNRIs) and other atypical antidepressants
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19
Q

They inhibit the reabsorption of serotonin and norepinephrine and elevate mood by increasing the level of serotonin, norepinephrine, and dopamine in the central nervous system

A

Duloxetine (Cymbalta)
Venlafaxine (Effexor)

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20
Q

Inhibit the reuptake of both norepinephrine and serotonin into presynaptic nerve terminals and is used mainly for major depression and occasionally for milder situational depression

A

TRICYCLIC ANTIDEPRESSANTS

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21
Q

Example of TCAs

A

Amitriptyline (Elavil)
Amoxapine (Asendin)
Imipramine (Tofranil)

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22
Q

Used for treatment of childhood enuresis

A

CLOMIPRAMINE (ANAFRANIL)

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23
Q

What is enuresis

A

Bedwetting

24
Q

CLOMIPRAMINE (ANAFRANIL) is approved treatment for ______

25
Most common side effect of TCA's
Orthostatic hypotension
26
The most serious adverse effect of TCA's
Cardiac dysrhythmias
27
Therapeutic effects of TCAs may take how many weeks to occur?
2 to 4
28
_____ is contraindicated in clients in the acute recovery phase of an MI, with heart block or with history of dysrhythmias, because of their effects on cardiac tissue
TCAs
29
Clients with urinary retention, narrow angle glaucoma or prostatic hypertrophy may not be good candidates for TCAs because of
anticholinergic side effects.
30
are pregnancy category C or D, so they are used during pregnancy or lactation only when medically necessary
Most TCAs
31
may decrease the efficacy of tricyclics
Oral contraceptive
32
Does smoking a cigarette diminishes the effects of TCAs
Yes
33
it will increase the rate of TCAs metabolism and excretion
Carbamazepine (Tegretol), Phenytoin (Dilantin), and rifampin (rifadin)
34
Does Tricyclic affect the efficacy of clonidine (catapres) and guanethidine (Ismelin)?
Yes
35
In TCAs, ________ interferes with their metabolism and excretion
Cimetidine (Tagamet)
36
Be aware that it may take _______ to achieve the full therapeutic effect of the drug (TCAs)
several weeks or more
37
What do SSRIs stand for?
SELECTIVE SEROTONIN REUPTAKE INHIBITORS
38
Drugs that slow the reuptake of the serotonin into presynaptic nerve terminals
SSRIs
39
SSRIs are the drug of choice in the treatment of _____ because of their favorable side effect profile
depression
40
Its function is to increase level of serotonin in the synaptic gap induce complex neurotransmitter changes in presynaptic and postsynaptic neurons in the brain. Presynaptic receptors become less sensitive and postsynaptic receptor become more sensitive.
SSRIs
41
SSRIs treat the following:
Major depression OCD Panic, phobias, PTSD
42
DRUG EXAMPLES OF SSRIs
Citalopram (Celexa) Escitalopram oxalate (Lexapro) Fluoxetine (Prozac) Fluvoxamine (Luvox) Paroxetine (Paxil) Sertraline (Zoloft)
43
Is a natural neurotransmitter in the CNS, found in high concentrations in certain neurons in hypothalamus, limbic system, medulla and spinal cord.
Serotonin
44
Is important to several body activities including the cycling between ______ and ____, ______and ____
NREM and REM sleep pain perception and emotional states
45
Its chemical name is 5-hydorxytryptamine (5-HT)
Serotonin
46
Most common side effects of SSRIs
Sexual dysfunction
47
A rare but serious disorder that affects the skin, mucous membrane, genitals and eyes
Steven-Johnson syndrome
48
Steven-Johnson syndrome is usually caused by an ________
unpredictable adverse reaction to certain medications
49
May occur when the client is taking in another medication that affects the metabolism, synthesis or reuptake of serotonin, causing serotonin to accumulate in the body
Serotonin syndrome
50
SES symptoms can begin as early as_____ after taking the first dose or as late as several weeks after the initiating pharmacotherapy
2 hours
51
Mental status changes (confusion, anxiety, restlessness) Hypertension, tremors Sweating, hyperpyrexia, or ataxia
S/Sx of SES
52
Note a history of_______, because SSRIs commonly cause weight gain, which may contribute to noncompliance in clients with distortions and concerns about body image
eating disorders
53
Ask the client about suicidal ideation, because the drugs may take______ before full therapeutic benefit is obtained
several weeks
54
SSRIs may take up to_____ to reach their maximum therapeutic effectiveness
5 weeks
55
Take most SSRIs in the _____ with food to avoid GI upset and insomnia.
morning
56
______ and ____maybe taken in the morning and evening
Lexapro and Zoloft
57
Take _____ at bedtime because it usually causes excessive drowsiness, especially at lower dose
Rameron