Anticonvulsants & Movement pharm

Question 1

What is levetiracetam used to treat?

Answer 1

generalized tonic clonic

simple partial

Question 2

What is the MOA of levetiracetam?

Answer 2

bind to SV2A and prevent hyper synchronization of seizures

- dec glutamate released

Question 3

What does Brivaracetam treat?

Answer 3

partial seizure

Question 4

What is the MOA of Brivaracetam?

Answer 4

SV2A with HIGH AFFINITY

inhibit Na channel and inc GABA release

Question 5

What is Lamotrigine used for?

Answer 5

tonic clonic and generalized partial seizures

Question 6

What is the MOA of Lamotrigine?

Answer 6

enhance Na channel inactivation

- inhibit repeated firing

Question 7

What is a major side effect of Lamotrigine?

Answer 7

SJS - steven johnson syndrome (rash)

Question 8

What does Divalproex and Valproate treat?

Answer 8

simple, complex, complex partial and absence seizure

preferred for myoclonic seizure

Question 9

What is the MOA of Divalproex and Valproate ?

Answer 9

inhibit GABA metabolism and prevent reuptake

- prolonged recovery of Na and Ca channels

Question 10

What are the adverse effects of Divalproex and Valproate?

Answer 10

weight gain, teratogenic, hepatotoxic

Question 11

What does Topiramate treat?

Answer 11

generalized tonic clonic and partial seizures

Question 12

What is the MOA of Topiramate?

Answer 12

inactivate of Na channels and inhibit reabsorption of HCO3-

Question 13

What are the adverse effects of Topiramate?

Answer 13

kidney stones, metabolic acidosis, SJS

Question 14

What does Zonisamide treat?

Answer 14

partial seizure

Question 15

What is the MOA of Zonisamide?

Answer 15

inhibit Na currents and T type Ca channels

Question 16

What are the adverse effects of Zonisamide?

Answer 16

weight loss, SJS, kidney stones

Question 17

What does Ethosuximide treat?

Answer 17

Absence seizure

Question 18

What is the MOA of Ethosuximide?

Answer 18

inhibit T type Ca channel

Question 19

What does Carbamazepine treat?

Answer 19

partial, generalized, mixed type seizure

Question 20

What is the MOA of Carbamazepine?

Answer 20

inhibit firing of Na channels

Question 21

What does Oxcarbazepine treat?

Answer 21

partial seizure

Question 22

What does Lacosamide treat?

Answer 22

partial seizure

Question 23

What is the MOA of Lacosamide?

Answer 23

inhibit voltage gated Na channel

Question 24

What are the major side effects of Lacosamide?

Answer 24

diplopia, N/V, slowed cardiac conduction

Question 25

What does Eslicarbazepine acetate treat?

Answer 25

partial seizure

Question 26

What is the MOA of Eslicarbazepine acetate?

Answer 26

stabilize inactivated Na channels

Question 27

What do Benzodiazepines treat?

Answer 27

EtOH withdrawal and status epileptics

Question 28

What is the MOA for Benzodiazepines?

Answer 28

increased freq of Cl channel openings

Question 29

What is the MOA of phenobarbital?

Answer 29

increased duration of GABA A open time

Question 30

What are the adverse effects of phenobarbital?

Answer 30

abuse potential, cognitive deficits, respiratory depression

Question 31

What is the MOA of phenytoin?

Answer 31

promotes Na efflux to stabilize threshold , decrease Ca influx , delay K outflow

Question 32

What adverse effects can Phenytoin cause?

Answer 32

gingival hyperplasia, folate def, SJS

Question 33

What does Gabapentin treat?

Answer 33

partial seizure

Question 34

What is the MOA of Gabapentin?

Answer 34

L type Ca channel

Question 35

What does Tiagabine treat?

Answer 35

partial therapy

Question 36

What is the MOA of Tiagabine?

Answer 36

block GAT-1 (GABA reuptake)

Question 37

What are some adverse effects of Tiagabine?

Answer 37

asthenia, confusion, dizziness

Question 38

What does Perampanel treat?

Answer 38

tonic clonic seizure | partial seizure

Question 39

What is the MOA of Perampanel?

Answer 39

noncompetitive antagonist of AMPA receptors

Question 40

What are the adverse effects of Cannabidiol?

Answer 40

increased liver enzymes

Question 41

What is the MOA of Levodopa?

Answer 41

Precursor to Dopamine - cross BBB - treat parkinson's

Question 42

What is the MOA of Amantadine ?

Answer 42

stimulate DA release and block reuptake | - treat parkinson's

Question 43

What is the MOA of selegiline?

Answer 43

MAOI and Antioxidant | - treat parkinson's

Question 44

Entacapone MOA

Answer 44

COMT inhibitor | - treat parkinson's

Question 45

What is the mechanism of Benztropine?

Answer 45

Muscarinic receptor blocker | - treat parkinson's

Question 46

MOA of Riluzole

Answer 46

inhibit Glutamate release | - ALS treat

Question 47

MOA of Baclofen

Answer 47

GABA receptor for symptomatic treatment of ALS