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CNS > Anticonvulsants & Movement pharm > Flashcards

Anticonvulsants & Movement pharm Flashcards

1
Q

What is levetiracetam used to treat?

A

generalized tonic clonic

simple partial

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2
Q

What is the MOA of levetiracetam?

A

bind to SV2A and prevent hyper synchronization of seizures

- dec glutamate released

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3
Q

What does Brivaracetam treat?

A

partial seizure

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4
Q

What is the MOA of Brivaracetam?

A

SV2A with HIGH AFFINITY

inhibit Na channel and inc GABA release

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5
Q

What is Lamotrigine used for?

A

tonic clonic and generalized partial seizures

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6
Q

What is the MOA of Lamotrigine?

A

enhance Na channel inactivation

- inhibit repeated firing

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7
Q

What is a major side effect of Lamotrigine?

A

SJS - steven johnson syndrome (rash)

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8
Q

What does Divalproex and Valproate treat?

A

simple, complex, complex partial and absence seizure

preferred for myoclonic seizure

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9
Q

What is the MOA of Divalproex and Valproate ?

A

inhibit GABA metabolism and prevent reuptake

- prolonged recovery of Na and Ca channels

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10
Q

What are the adverse effects of Divalproex and Valproate?

A

weight gain, teratogenic, hepatotoxic

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11
Q

What does Topiramate treat?

A

generalized tonic clonic and partial seizures

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12
Q

What is the MOA of Topiramate?

A

inactivate of Na channels and inhibit reabsorption of HCO3-

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13
Q

What are the adverse effects of Topiramate?

A

kidney stones, metabolic acidosis, SJS

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14
Q

What does Zonisamide treat?

A

partial seizure

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15
Q

What is the MOA of Zonisamide?

A

inhibit Na currents and T type Ca channels

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16
Q

What are the adverse effects of Zonisamide?

A

weight loss, SJS, kidney stones

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17
Q

What does Ethosuximide treat?

A

Absence seizure

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18
Q

What is the MOA of Ethosuximide?

A

inhibit T type Ca channel

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19
Q

What does Carbamazepine treat?

A

partial, generalized, mixed type seizure

20
Q

What is the MOA of Carbamazepine?

A

inhibit firing of Na channels

21
Q

What does Oxcarbazepine treat?

A

partial seizure

22
Q

What does Lacosamide treat?

A

partial seizure

23
Q

What is the MOA of Lacosamide?

A

inhibit voltage gated Na channel

24
Q

What are the major side effects of Lacosamide?

A

diplopia, N/V, slowed cardiac conduction

25
Q

What does Eslicarbazepine acetate treat?

A

partial seizure

26
Q

What is the MOA of Eslicarbazepine acetate?

A

stabilize inactivated Na channels

27
Q

What do Benzodiazepines treat?

A

EtOH withdrawal and status epileptics

28
Q

What is the MOA for Benzodiazepines?

A

increased freq of Cl channel openings

29
Q

What is the MOA of phenobarbital?

A

increased duration of GABA A open time

30
Q

What are the adverse effects of phenobarbital?

A

abuse potential, cognitive deficits, respiratory depression

31
Q

What is the MOA of phenytoin?

A

promotes Na efflux to stabilize threshold , decrease Ca influx , delay K outflow

32
Q

What adverse effects can Phenytoin cause?

A

gingival hyperplasia, folate def, SJS

33
Q

What does Gabapentin treat?

A

partial seizure

34
Q

What is the MOA of Gabapentin?

A

L type Ca channel

35
Q

What does Tiagabine treat?

A

partial therapy

36
Q

What is the MOA of Tiagabine?

A

block GAT-1 (GABA reuptake)

37
Q

What are some adverse effects of Tiagabine?

A

asthenia, confusion, dizziness

38
Q

What does Perampanel treat?

A

tonic clonic seizure

partial seizure

39
Q

What is the MOA of Perampanel?

A

noncompetitive antagonist of AMPA receptors

40
Q

What are the adverse effects of Cannabidiol?

A

increased liver enzymes

41
Q

What is the MOA of Levodopa?

A

Precursor to Dopamine

  • cross BBB
  • treat parkinson’s
42
Q

What is the MOA of Amantadine ?

A

stimulate DA release and block reuptake

- treat parkinson’s

43
Q

What is the MOA of selegiline?

A

MAOI and Antioxidant

- treat parkinson’s

44
Q

Entacapone MOA

A

COMT inhibitor

- treat parkinson’s

45
Q

What is the mechanism of Benztropine?

A

Muscarinic receptor blocker

- treat parkinson’s

46
Q

MOA of Riluzole

A

inhibit Glutamate release

- ALS treat

47
Q

MOA of Baclofen

A

GABA receptor for symptomatic treatment of ALS

CNS (7 decks)

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