Anticoagulants Flashcards
Pt time
12-15 seconds, prothrombin time
INR
0.8-1.2 person not receiving anticoagulants
INR for PE, DVT, A-Fib
2.0-3.0
INR for mechanical valves
3.0-4.0
PTT
25-35 seconds
How is heparin given?
With a 5/8in. needle 25 to 28 g, at a 90 degree angle
What is the antidote to heparin?
protamine sulfate
What is the antidote to lovenox?
protamine sulfate
What is the antidote for warfarin?
vitamin k
warfarin dietary guidelines
avoid alcohol, leafy greens eat consistently
Pradaxa antidote
No specific antidote, dialysis may remove
Do NOT administer heparin
IM
What intrinsic factor does coumadin act on?
IX
What intrinsic factors does heparin act on?
X & Xa
What factor does Coumadin act on?
X
What factor does Eliquis & Xarelto act on?
Xa
What factor does Pradaxa act on?
Thrombin
Clotting Sequence
X-Xa-Prothrombin-Thrombin-Fibrinogen-Fibrin
Process of Hemostasis
Injury to vessel, vessel spasm, formation of platelet plug, formation of fibrin clot, clot retraction, clot dissolution
What are indications for Anticoagulant therapy?
DVT, PE, MI, ischemic CVA, Chronic Atrial Fibrillation, Valve Replacement, DVT prophylaxix
Routes of Anticoagulants
Oral, IV, SQ
Route of Thrombolytics
IV