Anticoagulant and drugs acting on platelets

Question 1

What does Warfarin do?

Answer 1

Inhibits synthesis of coagulation factors II, VII IX and X

Question 2

What does Heparin do?

Answer 2

Herparin binds to antithrombin II and increase its effects. Anti-thrombin II inhibits thrombin and factor Xa

Question 3

How does ASA work and what effects does it have?

Answer 3

Action: Inhibits and deactivates COX

Effects:

• Prevent platelet aggregation
• Prostagladin favoring antiaggregatory effects

Question 4

What type of drug is clopidogrel?

Answer 4

Irreversible P2Y12 antagonist

Question 5

How does P2Y12 antagonists work and what effects does it have?

Answer 5

Action: Inhibit ADP to bind to P2Y12-receptor which inhibits the activation of GP IIb/IIIa receptor

Effects
-Platelets can no longer bind to fibrogen and each other

Question 6

How does dipyridamole work?

Answer 6

Action:
- Inhibits phosphodiesterase, which decreases the degregation of cAMP which inhibits platelets

• Inhibits uptake of adosine into erythrocytes -> more adosine avalible to inhibit platelets

Question 7

How does GPIIb/IIIa antagonists work?

Answer 7

Action

-Inhibits binding of fibrogen to GP IIb/IIIa -> inhibition of aggregation