Anti-inflammatory and immunosuppressive drugs

Question 1

How does NSAID work and what effect does it have?

Answer 1

Action: Acetylates COX

Effect: Has an anti inflammatory, anti pyretic and anagetic effects

Question 2

What type of drug is ASA?

Answer 2

Irreversible NSAID

Question 3

What type of drug is Ibuprofen?

Answer 3

Reversible NSAID

Question 4

How does paracetamol work and what effects does it have?

Answer 4

Action: Inhibits prostagladin synthesis in CNS

Effect: Reduce pain and fever

Question 5

How does cyclosporine work, what effect does it have and what is it used for?

Answer 5

Action: Inhibits mTOR -> inhibition of cellular proliferation which prolongates H1 phase of the cell cycle

Used to: prevent organ transplant rejection

Question 6

How does mycophenolate mofetil work and what effect does it have?

Answer 6

Inhibits purine biosynthesis

Question 7

How does azathioprine work?

Answer 7

It is a purine analogue and works by inhibiting of DNA-synthesis