anticancer pyrimidine and purine analogues Flashcards
1
Q
pyrimidine analogue
A
fluorouracil
uracil analogue
2
Q
what does fluorouracil interfere with
A
DTMP synthesis
converted into a Frudulent nucleotide (FDUMP)
3
Q
what does FDUMP interact with
A
thymidylate synthetase
cannot convert to DTMP
4
Q
whats the overall result of fluorouracil
A
inhibition of DNA
and not RNA or protein synthesis
5
Q
unwanted effects
A
gi epithelium damage
myelotoxicity
cerebellar distribution can also occur
6
Q
purine analogue
A
fludarabine
7
Q
what is fludarabine metabolised to
A
trisphosphate
8
Q
what does fludarabine inhibit and how
A
DNA synthesis
enters target cells
undergoes phosphorylation reaction as the endogenous nucleoside
inhibits DNA polymerase
