anticancer platinum compounds

Question 1

what are cisplatins used for

Answer 1

solid tumours of testes and ovaries

Question 2

whats the structure and attributes of cisplatin

Answer 2

water soluble planar coordination complex
central pl atom
2 chlorine atoms and 2 Nh2 surrounding it

Question 3

action of cisplatin

Answer 3

analogue of alkylating agents

Question 4

once it gains entry what does it do

Answer 4

cl- dissolves
leaving reactive complex
reacting with water then DNA

Question 5

what does it cause

Answer 5

intrastrand cross linking

between N7 and O6 of adjacent guanine molecules of G7

Question 6

what does the cross linking causes

Answer 6

results in local denaturation of DNA

Question 7

toxicity of cisplatin

Answer 7

seriously nephrotoxic
reacts with -sh in kindney tubules
strict regimen of hydration and diuresis must be taken
low myelotoxicity - nausea and vomiting

Question 8

what can reduce the nausea and vomiting

Answer 8

5-HT3 receptor antagonist

ondansetron

Question 9

another type of platin

Answer 9

carboplatin

Question 10

what is carboplatin

Answer 10

derivative of cisplatin
causes less nephrotoxicity, neurotoxicity, ototoxicity, nausea and vomiting
although more myelotoxicity