Anticancer

Question 1

What class of drugs inhibit the proliferation of cancer cells?

Answer 1

Cytotoxic drugs

Question 2

What are your cytotoxic drugs?

Answer 2

Alkylating

Antimetabolites

Cytotoxic Antibiotics

Plant Derivatives

Question 3

What class of drugs form covalent bonds within DNA strands, resulting in a cytostatic effect

Answer 3

Alkylating agents

Question 4

What class of drug blocks or subvert one or more metabolic pathways involved in DNA synthesis

Answer 4

Antimetabolites

Question 5

What class of drug forms stable complexes with DNA preventing replication

Answer 5

Cytotoxic Ab

Question 6

What class of drug affects microtubule function and the formation of the mitotic spindle?

Answer 6

Plant derivatives

Question 7

What class of drug inhibits tyrosine kinase. this doesn’t allow growth factor signals

Answer 7

Protein Kinase Inhibitors

Question 8

Are alkylating agents cytostatic effect limited to dividing cells?

Answer 8

No!

Question 9

What alkylating agent has to be activated in the liver?

Answer 9

Cyclophosphamide

Dacarbazine

Lomustine

Question 10

What tx sterile hemorrhagic cystitis

Answer 10

N-acetylcystein

Question 11

What alk agent has the lowest chance of toxicity?

Answer 11

Chlorambucil

Question 12

activation in the cell when Cl groups are replaced by hydroxyl groups and the complex becomes positively charged, interaction with proteins and nucleic acids of both RNA and DNA?

Answer 12

Cisplatin

Carboplatin

Question 13

Which is safer, and can be used in cats, cisplatin or carboplatin

Answer 13

Carboplatin

Question 14

What drug inhibits the production of nucleic acids and proteins essential for cell division and the cytoplasm?

Answer 14

Antimetabolites

Question 15

What drug competes for dihydrofolate reductase?

Answer 15

Methotrexate

Question 16

Which drug has a toxic effect on BM and GIT?

Answer 16

Methotrexate

Question 17

Tx for malignant lymphoma?

Answer 17

Methotrexate

Question 18

What drug inhibits thymidyalte synthase?

Answer 18

5 Fluorouracil

Question 19

What drug enhances the effect of 5-FU

Answer 19

MTX

Question 20

Which drugs bind to tubulin?

Answer 20

Vinca alkaloids:

Vincristine and vinblastine

Question 21

Tx of malignant lymphoma, cTVT

Answer 21

Vincristine

Question 22

What drug binds to microtubules, preventing normal dynamic reorganization?

Answer 22

Taxanes

Question 23

What are your SE of taxanes?

Answer 23

BM tox

Anaphylactic reactions

Question 24

What drug binds to DNA by intercalating causing single strand DNA breaks

Answer 24

Dactinomycin

Question 25

What drug triggers topoisomerase II dependent DNA fragmentation?

Answer 25

Doxorubicin

Question 26

What drug binds to DNA preventing replication?

Answer 26

Mitoxantrone

Question 27

What drug produces single and double strand breaks in the DNA creating free radicals?

Answer 27

Bleomycin

Question 28

What are your SE of l-asparaginase?

Answer 28

HS rxn Pancreatitis

Question 29

What are you tyrosine kinase inhibitors?

Answer 29

Imatinib Toceranib Mastinib

Question 30

What drug stimulates alveolar macrophages and promotes lymphocyte cytotoxicity?

Answer 30

BCG

Question 31

Tx of osteosarcoma?

Answer 31

BCG

Question 32

What transports growth regulator proteins and tumor suppressor genes out of the nucleus?

Answer 32

XPO-1 | exportin-1

Question 33

What drugs inhibit XPO-1?

Answer 33

Selinexor Verdinexor

Question 34

Tx of perianal gland tumors?

Answer 34

Delmadinone

Question 35

Mammary carcinomas?

Answer 35

Tamoxifen

Question 36

What cancer do you see Acute tumor lysis syndrome in?

Answer 36

Malignant lymphoma after chemo or radiotherapy

Question 37

Which drugs cause an acute type 1 HS rxn?

Answer 37

Doxorubicin l-asparaginase

Question 38

What drugs cause diarrhea? 3

Answer 38

MTX Doxorubicin Vincristine