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Pharmocology II > Anticancer > Flashcards

Anticancer Flashcards

1
Q

What class of drugs inhibit the proliferation of cancer cells?

A

Cytotoxic drugs

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2
Q

What are your cytotoxic drugs?

A

Alkylating

Antimetabolites

Cytotoxic Antibiotics

Plant Derivatives

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3
Q

What class of drugs form covalent bonds within DNA strands, resulting in a cytostatic effect

A

Alkylating agents

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4
Q

What class of drug blocks or subvert one or more metabolic pathways involved in DNA synthesis

A

Antimetabolites

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5
Q

What class of drug forms stable complexes with DNA preventing replication

A

Cytotoxic Ab

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6
Q

What class of drug affects microtubule function and the formation of the mitotic spindle?

A

Plant derivatives

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7
Q

What class of drug inhibits tyrosine kinase. this doesn’t allow growth factor signals

A

Protein Kinase Inhibitors

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8
Q

Are alkylating agents cytostatic effect limited to dividing cells?

A

No!

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9
Q

What alkylating agent has to be activated in the liver?

A

Cyclophosphamide

Dacarbazine

Lomustine

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10
Q

What tx sterile hemorrhagic cystitis

A

N-acetylcystein

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11
Q

What alk agent has the lowest chance of toxicity?

A

Chlorambucil

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12
Q

activation in the cell when Cl groups are replaced by hydroxyl groups and the complex becomes positively charged, interaction with proteins and nucleic acids of both RNA and DNA?

A

Cisplatin

Carboplatin

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13
Q

Which is safer, and can be used in cats, cisplatin or carboplatin

A

Carboplatin

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14
Q

What drug inhibits the production of nucleic acids and proteins essential for cell division and the cytoplasm?

A

Antimetabolites

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15
Q

What drug competes for dihydrofolate reductase?

A

Methotrexate

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16
Q

Which drug has a toxic effect on BM and GIT?

A

Methotrexate

17
Q

Tx for malignant lymphoma?

A

Methotrexate

18
Q

What drug inhibits thymidyalte synthase?

A

5 Fluorouracil

19
Q

What drug enhances the effect of 5-FU

A

MTX

20
Q

Which drugs bind to tubulin?

A

Vinca alkaloids:

Vincristine and vinblastine

21
Q

Tx of malignant lymphoma, cTVT

A

Vincristine

22
Q

What drug binds to microtubules, preventing normal dynamic reorganization?

A

Taxanes

23
Q

What are your SE of taxanes?

A

BM tox

Anaphylactic reactions

24
Q

What drug binds to DNA by intercalating causing single strand DNA breaks

A

Dactinomycin

25
Q

What drug triggers topoisomerase II dependent DNA fragmentation?

A

Doxorubicin

26
Q

What drug binds to DNA preventing replication?

A

Mitoxantrone

27
Q

What drug produces single and double strand breaks in the DNA creating free radicals?

A

Bleomycin

28
Q

What are your SE of l-asparaginase?

A

HS rxn

Pancreatitis

29
Q

What are you tyrosine kinase inhibitors?

A

Imatinib

Toceranib

Mastinib

30
Q

What drug stimulates alveolar macrophages and promotes lymphocyte cytotoxicity?

A

BCG

31
Q

Tx of osteosarcoma?

A

BCG

32
Q

What transports growth regulator proteins and tumor suppressor genes out of the nucleus?

A

XPO-1

exportin-1

33
Q

What drugs inhibit XPO-1?

A

Selinexor

Verdinexor

34
Q

Tx of perianal gland tumors?

A

Delmadinone

35
Q

Mammary carcinomas?

A

Tamoxifen

36
Q

What cancer do you see Acute tumor lysis syndrome in?

A

Malignant lymphoma after chemo or radiotherapy

37
Q

Which drugs cause an acute type 1 HS rxn?

A

Doxorubicin

l-asparaginase

38
Q

What drugs cause diarrhea? 3

A

MTX
Doxorubicin
Vincristine

Pharmocology II (6 decks)

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