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Block 4- Kim > Antibiotics MOA > Flashcards

Antibiotics MOA Flashcards

1
Q

D: Infection

A

Invasion & Multiplication of pathogenic microbes

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2
Q

D: Antibiotic

A

Anti-bacterial medication (not including disinfectants)

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3
Q

D: Antibacterial

A

Kills or inhibits growth of bacteria

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4
Q

D: Bactericidal

A

Kills bacteria (affects bacterial cell wall)

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5
Q

D: Bacteriostatic

A

Inhibits bacteria growth (affecting RNA/DNA)

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6
Q

D: Broad spectrum Abx

A

Active against many bacteria (may kill normal flora)

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7
Q

D: Narrow spectrum Abx

A

Active against a few bacteria (may not kill all pathogens)

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8
Q

Minimum Bactericidal Concentration (MBC)

A

Lowest concentration that kills 99.9% of a population

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9
Q

Minimum inhibitory concentration

A

Lowest concentration which inhibits visible growth of bacteria

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10
Q

D: Breakpoint

A

MIC cut-of which separates strains where there is a high likelihood of tx succeeding from those where tx is more likely to fail

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11
Q

What would you use against Tonsilitis?

Give name, class, MOA + any extras & SE

A

Penicillin

Class: Beta- Lactam- Penicillins

MOA: Bacteriocidal (inhibit synthesis of cell wall -> Cell lysis)

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12
Q

What would you use against SSTI Straph. A initially?

Give name, class, any extras & SE

A

Flucloxacillin

Beta Lactam- Penicillin

MOA: Bacteriocidal- Penicillinase Resistant

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13
Q

What would you use against SSTI strep

Give name, class, any extras & SE

A

Benzylpenicillin

Beta Lactam- Penicillin

MOA: Bacteriocidal

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14
Q

What would you use against LRTI

Give name, class, any extras & SE

A

Amoxicillin

Beta- Lactam Penicillin

MOA: Bacteriocidal + Enhanced uptake by bacteria

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15
Q

What would you use against Mixed infections?

Give name, class, any extras & SE

A

Co-Amoxiclav

Beta Lactam- Penicillin

MOA: Bacteriocidal + Beta Lactamase Inhibitor

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16
Q

What are the Bacteriocidal Drug Classes?

A

Beta Lactams: Penicillins, Cephlosporins & Carbapenems

17
Q

When would you use Fluclox?

A

SSTI Staph A

18
Q

When would you use Benpen?

A

SSTI Strep

19
Q

When would you use Amoxicillin?

A

LRTI

20
Q

When would you use Co- Amoxiclav?

A

Mixed Chest infections

21
Q

When would you use Penicillin?

A

Tonsilitis

22
Q

What would you use against Infections in ITU/ Complex, Multidrug resistant UTIs

Give name, class, any extras & SE

A

Meropenem

Class: Beta Lactam Carbapenem

MOA: Bacteriocidal

23
Q

When would you use meropenem?

A

Infections in ITU

Complex, Multidrug resistant UTIs

24
Q

What would you use against: Bacterial meningitis, Abdominal Sepsis, Othro Infections?

Give name, class, any extras & SE

A

Cefatriaxone

Class: Beta Lactam- Cephlasporins

MOA: Bacteriocidal

SE: CDAD and 10% w/ penicillin allergy have alergy to this

Extra: Later generations increased acitivity spectrum but:

a) Kill more natural flora
b) Decreased activity against Gram +ve

25
Q

When do you use cefatriaxone?

A

Abdo sepsis, Ortho infections, Bacterial meningitis

26
Q

What are the Bacteriostatic drug clases?

A

Macrolides- Erythromyocin

Lincosimides- Clindamyocin

Tetracyclines- Tetra & Doxyclcyline

27
Q

What would you use against URTI, LRTI, SSTI, Atypical LRTI

Give name, class, any extras & SE

A

Erythromyocin

Class: Macrolide

MOA: Bacteriostatic

Notes: In place of penicillin. Atypical LRTI- eg: legionella

28
Q

What would you use Erythromyocin for?

A

LRTI, URTI, Atypical LRTI (eg: legionella), SSTI

In place of penicillin

29
Q

What would you use against SSTI in place of penicillin

Give name, class, any extras & SE

A

Clindomyocin

Class: Lincosamide

MOA: Bacteriostatic

NOTES: In place of penicillin when IV access is limitied. Excellent bioavailability & tissue penetration when taken orally

30
Q

What would you use against an SSTI in place of penicillin?

A

Clindamyocin (Lincosimide)

31
Q

What would you use against Atypical Bacterial that lack a cell wall (eg: Chlamydia, Myoplasma Rickettsia infections eg: typhus)

Give name, class, any extras & SE

A

Tetracycline/ Doxycycline

Class: Tetracyclines

MOA: Bacteriostatic

SE: Photosensitivity, GI upset- Reflux, Oesophagitis, Diarrhoea

32
Q

When would you use Tetracyclines?

A

Atypical Bacteria that lack cell wall (eg: Chlamydia, Mycoplasma Rickettsia infections eg: typhus)

33
Q

What are the Bacterial DNA strucutre & Function Abx?

A

Nitromedazole

Fluroquinolones- Cipro

34
Q

What would you use against: Anaerobic infections (absecess)

Give name, class, any extras & SE

A

Metronidazole

Class: Nitromidazole

MOA: Bacterial DNA Strucutre & Function

35
Q

When would you use Metranidazole?

A

Anaerobic infections (abscess)

36
Q

What would you use against: Grame -ve infections, MRSA?

Give name, class, any extras & SE

A

Ciprofloxacin

Class: Fluroqionolones

MOA: Bacterial DNA Structure & Function

SE: CDAD

37
Q

When would you use Ciprofloxacin?

A

Gram -ve infections (excluding anaerobes)

MRSA infections

38
Q

Which drugs induce CDAD?

A

Ciprofloxicin & Cefatriaxone

39
Q

What wold you use in place of Penicillin?

A

Macrolides- Erythromyocin

Lincosamides- Clindamyocin

Block 4- Kim (13 decks)

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