Antibiotics

Question 1

Name possible mechanisms for the post antibiotic effect

Answer 1

Slow recovery of bacteria, persistence of antibiotic binding at target side, bacteria may need to synthesize new enzymes for growth

Question 2

Name two antibiotics with strong PAE, moderate PAEAE, and week PAE

Answer 2

Strong: concentration-dependent kill characteristics: Aminoglkoside, tetracycline
Moderate: time-dependent kill characteristics: carbapenems, glykopeptids
Weak: ß-lactame, cephalosporine