antibiotic therapy 2 Flashcards
why are most protein synthesis inhibitors bacteriostatic
as protein syntheiss can usually resume when antibiotic is removed
exception of protein synthesis inhibitors which are bactericidal
aminoglycosides
protein synthesis inhibitors
aminoglycosides
tetracyclines
macrolides
example of aminoglycoside
gentamicin
example of macrolide
erythromycin
how must gentamicin be given
iv as not absorbed from gut
which ribosomes do aminoglycosides bind to
30s ribosome inhibitng protein syntheiss
wwhat damage can aminoglycosides do
damage to kidneys and 8th cranial nerve
are tetracyclines cidal static
static
What do tetracycline sbind to
30s subunit and prevent attachment of trna to acceptor sites
are macrolides bacteriostatic or cidal
static
what do macrolides bind to
50s subunit binding and block translocation no release of peptide
what are erythromycin and clarithyromycin active agaisnt
gram negativewh
what is azithyromycin activce agaisnt
gram positive
antibiiotics which target nucelic acids
fluoroquinolones
metronidazole
trimethoprim
rifampicin
rifampin
what is metronidazole active agaisnt
anaerobes and protozoa
what are flouroquinolones active against
gram neg and pos
are quinolones cidal or static
cidal
what is ciprofloxacin active agaisnt
mostly gram neg
. E. coli, H. influenza, Pseudomonas, Moraxella, Legionella
metallic taste, furred tongue
metronidazole
action of metronidazole
forms toxic intermediate which breaks dna strands
presumptive diagnosis
prescribing antibiotics without lab identification
targeted prescribing
lab investigation made
what to avoid in pregnancy/ breats feeding women
ciprofloxacin
4cs
Cephalosporins
Co-amoxiclav
Ciprofloxacin
Clindamycin
