Antibiotic allergy and fever in returned traveller Flashcards
haptenization
drugs cannot induce allergic reaction without being bound to a protein
cephalosporin haptenization is less efficient
red man syndrome
giving vancolycin too quick
arm turns red due to activiating receptors mediating granulation
stephen johnson syndrome
skin blisters due to dermal epidermal junction dysruption
abnormal liver and renal dysfunction coincides
T cell driven
DRESS
drug reaction with eosinophilia and systemic symptoms
oedema on face
liver and kidney dysfunction
eosinophilia
T cell driven
AGEP
acute generalised exanthemous pustulosis
sterile pustulosis
T cell driven
penecillin allergic reaction
can fade over time
Pen FAST allergy tool
five years or less
allergy eg. what was the reaction
severe
treatment - did they need hospital
scoring system - low score implies allergy is unlikley
what kind of risk factors can you look for in returned travellers
sexual
animal exposure
arthropod eg. mosquitos, flies, ticks, fleas, mites, lice bugs
needle and blood exposure
unclean water or undercooked food
soil and water contact
animal diseases in australia
toxoplasmosis - cats
Qfever - cattle, sheep goats
avian flu - birds
horses and bats - australian rabies
reduviid bugs
chagas disease
malaria
there is no malaria in Bali but test anyway because you dont know if they visited one of the islands or something
anopheles species of mosquito
typhus
resembles typhoid clinically
caused by ricketsia species
making an assessment of the malaria severity
severe malaria needs IV therapy
main thing about dengue
fluid balance
use haematocrit and skin turgor/other signs
patient will enter critical phase at the end of the fever and will start plasma leakage - fluid will be dumped into brain and lungs and they’ll die
