Antiarrhythmics - Overview

Question 1

MOA of each class

Answer 1

• Class I – Sodium channel blockers
• Class II – Beta-blockers
• Class III – Potassium channel blockers
• Class IV – Calcium channel blockers
• Memory aid:*
• _S_ome _B_lock _P_otassium _C_hannels

Question 2

Toxicity of antiarrhythmics

Answer 2

Lead to torsades de pointes, which is associated with long QT syndrome

Question 3

A patient on procainamide for an arrhythmia develops facial rash and joint pain. She is found to have antihistone antibodies in her serum. What is the diagnosis?

Answer 3

Reversible systemic lupus erythematosus-like syndrome

Question 4

Class IA drugs

Answer 4

• Quinidine
• Procainamide
• Disopyramide
• Memory aid:*
• The _Quee_n _Proc_laims Diso’s _pyrami_d

Question 5

Class IB drugs

Answer 5

• Lidocaine
• Mexiletine
• Memory aid:*
• I’d _B_uy _Lid_dy’s _Mex_ican Tacos

Question 6

Class IC drugs

Answer 6

• Flecainide
• Propafenone
• Memory aid:*
• IC-F-P

Question 7

Class III drugs

Answer 7

• Amiodarone
• Ibutilide
• Dofetilide
• Sotalol
• Memory aid:*
• Pota, may AIDS!