Anti-Viral Agents Flashcards

1
Q

MOA of NRTIs and contraindications EXCEPT

A

Impair mitochondrial function by inhibiting DNA y-Polymerase and binds to reverse transcriptase to inhibit viral replication

RENAL IMPAIRMENT except ABC (liver impairment)

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2
Q

Tell me about AZT

A

adverse effects- bone marrow toxicity, peripheral neuropathy

NB - Good CNS penetration, DDI with valproate

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3
Q

Which of the NRTIs is nephrotoxic?

A

TDF (Fanconi Syndrome), Decreased bone mineral density

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4
Q

Lamivudine (3TC) - adverse effect, although it’s rare

A

pure red cell aplasia

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5
Q

FTC - adverse effects (HHH)

A
  1. Headache
  2. Severe Skin, Hypersensitivity Reactions
  3. Hyperpigmentation of palms and soles
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6
Q

ABC severe?

A

hypersensitivity!

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7
Q

MOA of INSTI?

A

inhibits intergration of viral DNA

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8
Q

contraindications to INSTI?

A

Pregnancy in the 1st trimester

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9
Q

where is NVP soooo important?

A

PMTCT

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10
Q

porphyria

A

lopinavir/ritonavir

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11
Q

Which ART is rifampicin contraindicated in

A

NVP,3rd line PI agents

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12
Q

NVP has serious side effects. Which ones are they?

A

severe skin reactions - SJS

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13
Q

Alternative drug use to DTG in pregnancy

A

raltegravir

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14
Q

which is the preferred PI combination in diabetic?

A

atazanavir + ritonavir (RTV) combo

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