Anti-Viral Agents Flashcards
MOA of NRTIs and contraindications EXCEPT
Impair mitochondrial function by inhibiting DNA y-Polymerase and binds to reverse transcriptase to inhibit viral replication
RENAL IMPAIRMENT except ABC (liver impairment)
Tell me about AZT
adverse effects- bone marrow toxicity, peripheral neuropathy
NB - Good CNS penetration, DDI with valproate
Which of the NRTIs is nephrotoxic?
TDF (Fanconi Syndrome), Decreased bone mineral density
Lamivudine (3TC) - adverse effect, although it’s rare
pure red cell aplasia
FTC - adverse effects (HHH)
- Headache
- Severe Skin, Hypersensitivity Reactions
- Hyperpigmentation of palms and soles
ABC severe?
hypersensitivity!
MOA of INSTI?
inhibits intergration of viral DNA
contraindications to INSTI?
Pregnancy in the 1st trimester
where is NVP soooo important?
PMTCT
porphyria
lopinavir/ritonavir
Which ART is rifampicin contraindicated in
NVP,3rd line PI agents
NVP has serious side effects. Which ones are they?
severe skin reactions - SJS
Alternative drug use to DTG in pregnancy
raltegravir
which is the preferred PI combination in diabetic?
atazanavir + ritonavir (RTV) combo