Anti-Viral Agents

Question 1

MOA of NRTIs and contraindications EXCEPT

Answer 1

Impair mitochondrial function by inhibiting DNA y-Polymerase and binds to reverse transcriptase to inhibit viral replication

RENAL IMPAIRMENT except ABC (liver impairment)

Question 2

Tell me about AZT

Answer 2

adverse effects- bone marrow toxicity, peripheral neuropathy

NB - Good CNS penetration, DDI with valproate

Question 3

Which of the NRTIs is nephrotoxic?

Answer 3

TDF (Fanconi Syndrome), Decreased bone mineral density

Question 4

Lamivudine (3TC) - adverse effect, although it’s rare

Answer 4

pure red cell aplasia

Question 5

FTC - adverse effects (HHH)

Answer 5

1. Headache
2. Severe Skin, Hypersensitivity Reactions
3. Hyperpigmentation of palms and soles

Question 6

ABC severe?

Answer 6

hypersensitivity!

Question 7

MOA of INSTI?

Answer 7

inhibits intergration of viral DNA

Question 8

contraindications to INSTI?

Answer 8

Pregnancy in the 1st trimester

Question 9

where is NVP soooo important?

Answer 9

PMTCT

Question 10

porphyria

Answer 10

lopinavir/ritonavir

Question 11

Which ART is rifampicin contraindicated in

Answer 11

NVP,3rd line PI agents

Question 12

NVP has serious side effects. Which ones are they?

Answer 12

severe skin reactions - SJS

Question 13

Alternative drug use to DTG in pregnancy

Answer 13

raltegravir

Question 14

which is the preferred PI combination in diabetic?

Answer 14

atazanavir + ritonavir (RTV) combo