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Pharmacology > Anti-Malarial Drugs > Flashcards

Anti-Malarial Drugs Flashcards

1
Q

1st choice anti-malarial?

A

artesunate, but not used in SA

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2
Q

red is a primary colour. which anti-malarial has an adverse effect related to this?

A

artesunate and primaquine- haemolytic anaemia

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3
Q

what is the treatment of uncomplicated malaria?

A

Artemether

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4
Q

which anti-malarial should be taken with another long acting drug

A

quinine

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5
Q

the adverse effects of quinine are?

A

Cinchonism and hypersensitivity reactions

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6
Q

which is the anti-malarial used in pregnancy?

A

mefloquine

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7
Q

which anti-malarial is used for the prevention of relapse for p.ovale and p.vivax?

A

primaquine

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8
Q

what is proguanil?

A

anti-folate used for malaria prophylaxis

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9
Q

which anti-microbial is used as prophylaxis to malaria?

A

clindamycin and proguanil

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10
Q

different types of malaria

A

plasmodium, vivax, ovale, malariae

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11
Q

severe vs complicated malaria

A

artesunate vs artemether

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12
Q

what should you add to artemether

A

lufemantrine (coartem)

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13
Q

quinine

A

uncomplicated and severe malaria

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14
Q

MOA for quinine - the enyzme.

A

haem polymerase

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15
Q

IV Quinine has its own side effects. What are they? Clue: queen of hearts

A

cardiac dysrhythmias, blindness, deafness

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16
Q

quinine also stimulates the production of something. Clue: you are so sweet!

A

hypoglycemia for insulin

17
Q

hypnozoite - which drug works here (3)

A

primaquine

18
Q

active against gametocytes?

A

artemisin derivatives

19
Q

malanil

A

atovaquone + proguanil

20
Q

use of doxycycline

A

prophylaxis, add on to quinine for falciparum malaria

21
Q

side effects of doxycycline: similar to tetracycline

A

teeth staining, decreased bone growth, photosensitivity, candidasis, oesophagitis

22
Q

clindamycin

A

safe in pregnancy

23
Q

need to give prophylaxis. DAMN

A

doxycycline
atovaquone/proguanil
mefloquine

24
Q

non falciparum malaria what do you give

A

chlorquine + primaquine if p.ovale/p.vivax

Pharmacology (11 decks)

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