Anti-Malarial Drugs Flashcards
1st choice anti-malarial?
artesunate, but not used in SA
red is a primary colour. which anti-malarial has an adverse effect related to this?
artesunate and primaquine- haemolytic anaemia
what is the treatment of uncomplicated malaria?
Artemether
which anti-malarial should be taken with another long acting drug
quinine
the adverse effects of quinine are?
Cinchonism and hypersensitivity reactions
which is the anti-malarial used in pregnancy?
mefloquine
which anti-malarial is used for the prevention of relapse for p.ovale and p.vivax?
primaquine
what is proguanil?
anti-folate used for malaria prophylaxis
which anti-microbial is used as prophylaxis to malaria?
clindamycin and proguanil
different types of malaria
plasmodium, vivax, ovale, malariae
severe vs complicated malaria
artesunate vs artemether
what should you add to artemether
lufemantrine (coartem)
quinine
uncomplicated and severe malaria
MOA for quinine - the enyzme.
haem polymerase
IV Quinine has its own side effects. What are they? Clue: queen of hearts
cardiac dysrhythmias, blindness, deafness
quinine also stimulates the production of something. Clue: you are so sweet!
hypoglycemia for insulin
hypnozoite - which drug works here (3)
primaquine
active against gametocytes?
artemisin derivatives
malanil
atovaquone + proguanil
use of doxycycline
prophylaxis, add on to quinine for falciparum malaria
side effects of doxycycline: similar to tetracycline
teeth staining, decreased bone growth, photosensitivity, candidasis, oesophagitis
clindamycin
safe in pregnancy
need to give prophylaxis. DAMN
doxycycline
atovaquone/proguanil
mefloquine
non falciparum malaria what do you give
chlorquine + primaquine if p.ovale/p.vivax
