Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BMS 242 Core Physiology and Pharmacology > Anti-Inflammatory and Immunosuppressant Drugs > Flashcards

Anti-Inflammatory and Immunosuppressant Drugs Flashcards

1
Q

What does NSAID stand for

A

non steroidal anti inflammatory drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What do NSAIDs decrease the production of

A

prostaglandins and thromboxane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the properties of NSAIDs

A

anti-inflammatory, analgesic, antipyretic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the effect of prostaglandins in damaged and inflammed tissue

A

sensitises nociceptors to inflammatory mediators

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the effect of the anti-inflammatory property of NSAIDs

A

decrease vasodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the two isoforms of COX

A

COX1 and COX2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which COX isoform exhibits inducible expression

A

COX2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Where is COX1 expressed

A

platelets, stomach, colon, most tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where is COX2 expressed

A

most cells, kidney, inflammatory cells after stimulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What can stimulate inflammatory cells to express COX2

A

cytokines, growth factors, tumor promoters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the side effects of NSAIDs

A

renal failure, liver damage, skin rashes, bronchospasm, affects the gut

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the function of prostaglandins in the gut

A

inhibit acid secretion and protect mucosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which NSAID has the highest risk of GI complications

A

azapropazone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is an undesirable side effect from COX1 inhibition by NSAIDs

A

gastrotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is an undesirable side effect from COX2 inhibition by NSAIDs

A

increase BP, salt retention,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What aspirin bind to in COX

A

covalently to COX residue

17
Q

What does aspirin binding to Ser residue in COX prevent

A

arachadonic acid from reaching the cyclo-oxygenase site

18
Q

What diseases can aspirin reduce the risk of

A

colonic and rectal cancer, alzheimer’s

19
Q

Where is paracetamol metabolised

A

liver

20
Q

What type of drug is paracetamol

A

competitive inhibitor

21
Q

What type of drug is aspirin

A

suicide inhibitor - irreversible

22
Q

What can aspirin be used for

A

reduce risk of arterial thrombosis

BMS 242 Core Physiology and Pharmacology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions