Anti-Fungal Part 5 Flashcards

1
Q

Orally used for systemic mycoses

Available as 2% cream

Known to inhibit cholesterol biosynthesis

The only water soluble

Adverse effect: Hepatotoxic

A

Ketoconazole Nizoral ®

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2
Q

Supplied as 1% cream used for candidiasis

A

Econazole nitrate (Spectrazole)

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3
Q

As1%creamforlocaltinea infections

A

Sulconazole nitrate (Exelderm)

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4
Q

More effective against Torulopsis glabarata, supplied as 6.5% ointment

A

Tioconazole

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5
Q

Local and systemic infections in injectable form

A

Miconazole

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6
Q

Acidic environment is required, reduce acidity reduces the GI absorption of the drug.

Effective and better tolerated than Ketoconazole

A

Itraconazole (Sporanox)

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7
Q

Treatment of choice for Cryptococcal meningitides, plasma binding is less than 10%

A

Fluconazole Diflucan ©

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8
Q

Acts as a tight-binding noncompetitive inhibitor of the enzyme inositol phosphoryl ceramide synthase

Produced by fermentation in cultures of Aureobasidin
pullulan

A

Aureobasidin A

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9
Q

Napthacenequinones that bind mannan in the presence of Ca2+ to disrupt the cell membrane in pathogenic fungi

Against Candida spp. And Cryptococcus neoforman

A

Pradimycins and Benanomycin

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