Anti-Fungal Part 5 Flashcards
Orally used for systemic mycoses
Available as 2% cream
Known to inhibit cholesterol biosynthesis
The only water soluble
Adverse effect: Hepatotoxic
Ketoconazole Nizoral ®
Supplied as 1% cream used for candidiasis
Econazole nitrate (Spectrazole)
As1%creamforlocaltinea infections
Sulconazole nitrate (Exelderm)
More effective against Torulopsis glabarata, supplied as 6.5% ointment
Tioconazole
Local and systemic infections in injectable form
Miconazole
Acidic environment is required, reduce acidity reduces the GI absorption of the drug.
Effective and better tolerated than Ketoconazole
Itraconazole (Sporanox)
Treatment of choice for Cryptococcal meningitides, plasma binding is less than 10%
Fluconazole Diflucan ©
Acts as a tight-binding noncompetitive inhibitor of the enzyme inositol phosphoryl ceramide synthase
Produced by fermentation in cultures of Aureobasidin
pullulan
Aureobasidin A
Napthacenequinones that bind mannan in the presence of Ca2+ to disrupt the cell membrane in pathogenic fungi
Against Candida spp. And Cryptococcus neoforman
Pradimycins and Benanomycin