Anti-Fungal Part 1 Flashcards
Discovered Trichophyton schoenleinii
Schönlein and Gruby
Discovered C. albicans
Bernhard Von Langenbec
Topical agents for dermatophytosis
Fatty acids
SAR of Fatty acids
higher molecular weight members have the advantage of having lower volatility
Structure similar to sebum, a natural antifungal
Sodium and calcium propionates
Uses: preservative, for dermatomycosis
Propionic acid
Found in coconut and palm oil
Prepared from caprylic acid
Sodium Caprylate
Used as topical fungicide
Astringency of zinc decreases inflammation and wetness
Zinc Caprylate
Fungicide on adhesive tape
Zinc Propionate
Iupac of Undecylenic acid
10-Undecenoic acid
The primary fungicide for diaper rash
Sodium undecylenate
Destructive distillation of castor oil (Decenex ®, Cruex ®)
Undecylenic acid
Fungicidal properties are due to acetic acid formation, action is self-limiting because esterase are inactivated below a pH of 4
Triacetin (Enzactin, Fungacetin)
Antiseptic and keratolytic Commonly combined with benzoic acid to form an ointment
Salicylic acid
This ointment contains 6% benzoic acid and 6% salicylic acid in a petrolatum base
Whitfield’s ointment