Anti-Fungal Part 3 Flashcards

1
Q

5-Fluorocytosine + Amphotericin =

A

Cryptococcal meningitis

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2
Q

5-Fluorocytosine + Itraconazole

A

Chromoblastomycosis

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3
Q

Orally active antifungal

Very narrow spectrum of activity, prone to resistance

Orally active antifungal

For serious systemic infections caused by Candida and Cryptococcus sp.

A

5-Fluorocytosine

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4
Q

agents that contain, in their structure, at least two double bonds, and a lactone ring.

A

Antifungal antibiotics (Polyenes)

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5
Q

broad spectrum antifungal agents with potent activity against yeasts, molds, and dermatophytes

A

Antifungal antibiotics (Polyenes)

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6
Q

The most effective agent in the treatment of systemic fungal infection (IV- severe form) especially the immunocompromised patient

A

Amphotericin B (Fungizone)

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7
Q

Amphotericin B has Fungistatic at low concentration; fungicidal at high concentration T/F

A

True

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8
Q

Side effects of Amphotericin B

A

Phlebitis
Chills
Nephrotoxicity
Hemolytic activity

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9
Q

Amphotericin B Binds to ergosterol and alters the permeability of the cell by forming amphotericin 𝛽-associated pores in the cell membrane. T/F

A

True

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10
Q

The smallest type of macrocycle; a pentaene

Obtained from cultures of S. natalensis

Used topically to treat superficial mycotic infections of the eye

A

Natamycin (Also known as Pimaricin)

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11
Q

Natamycin (Pimaricin) Causes both potassium ion leakage and cell lysis at the same concentration. T/F

A

True

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12
Q

Penicillium griseofulvum

Used for Systemic treatment of tinea infections/dermatophytosis

Refractory ringworm infections of body, nails, hair, and feet

A

Griseofulvin

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13
Q

Griseofulvin Oral absorption provides a systemic effect; should be given with a fatty meal
T/F

A

True

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14
Q

Griseofulvin Inhibits fungal cell activity by interfering with mitotic spindle structure T/F

A

True

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