Anti-Emetics Flashcards
Reglan
Name
Metoclopramide
Reglan
Class
Antiemetic
Reglan
Description
Metoclopramide is a dopamine antagonist similar to procainamide but with few antidysrhythmic or anesthetic properties. Its antiemetic properties stem from rapid gastric emptying and desensitization of the vomiting reflex
Reglan
Indication
Nausea and vomiting
Reglan
Contraindications
Hypersensitivity, seizure disorders, GI obstruction or perforation and breast cancer
Reglan
Precautions
CHF, hypokalemia, renal impairment, GI hemorrhage, intermittent porphyria
Reglan
Dosage/Route
10-20 mg IM; 10mg Slow IV (over 2-4 minutes)
Pedi: 1-2 mg/kg/dose
Promethazine
Name
Phenergan
Promethazine
Class
Antiemetic
Promethazine
Description
Promethazine is an anti-cholinergic agent that enhances the effects of analgesics and is a potent antiemetic
Promethazine
Indications
Nausea and vomiting, motion sickness, to enhance the effects of analgesics, and to induce sedation
Promethazine
Contraindications
None
Promethazine
Precautions
Hepatic, respiratory or cardiac impairment, asthma, hypertension, elderly or debilitated patients
Promethazine
Dosage/Route
12.5-25 mg IV/IM/PR
Pedi: 0.5 mg/kg IV/IM/PR
Compazine
Name
Prochlorperazine
Compazine
Class
Antiemetic
Compazine
Indications
Severe nausea and vomiting, acute psychosis
Zofran
Name
Zofran
Zofran
Class
antiemetic
Zofran
Description
selective blocking agent of the serotonin 5-ht3 receptor type
Zofran
Indications
Prevention of nausea and intractible vomiting
Zofran
Contraindications
none
Zofran
Precautions
may mask a progressive ileus and or gastric distention, long qt syndrome
Zofran
Dosage/Route
4mg IVP or single 4-mg tablet ODT
