Anti Clotting Mechanisms Of The Endothelium

Question 1

What is a clot

Answer 1

A platelet plug then a fibrin clot

Question 2

6 anticlot mechanisms of the endothelium

Answer 2

Stops blood contacting collagen (no platelet aggregation)

Produces prostacyclin and NO (both inhibit platelet aggregation)

Produces tissue factor pathway inhibitor (TFPI stops thrombin production)

Expresses thrombomodulin and heparin (inactivate thrombin)

secretes tissue plasminogen activator (t-PA turns into plasmin and digests clot)