Anti-Anxiety Agents Flashcards
what is GAD
generalized anxiety disorder
describe GAD
excessive uncontrollable worry about everyday issues w/ physical manifestations
describe the pathology of anxiety disorders
GABA through the GABA-A receptor is mainly inhibitory in the brain. The receptor is a ligand gated chloride channel. Cl- ions moving intracellularly, results in hyperpolarization and inhibition of the neuron.
from what has been seen about the pathology of anxiety disorders, abnormalities in the GABA-A receptor may therefore lead to
hyperactivity or anxiety issues
what is the general name for current anxiolytics?
benxodiazepines
BZDs
give examples of benzodiazepines
alprazolam – xanax
diazepam – valium
what are some characteristics of benzodiazepines?
- high TI
- overdose is rare when taken alone
what are the indications of BZDs?
- anxiety
- insomnia
- epilepsy
- preanesthetic
- induction and maintenance of anesthesia
- alcohol withdrawal
benzodiazepines are ___________ that act on what type of receptors?
- allosteric modulators
- GABA-A receptors
benzodiazepines enhance _________ binding to the receptor therefore increasing the….
- GABA
- frequency of opening Cl- ions
barbiturates are aka
phenobarbitual
barbiturates act independently of
GABA binding
barbiturates promote..
what does this increase?
benzodiazepine binding to GABA-A receptor
increases: the duration of chloride channel opening
non-benzodiazepine anxiolytics are…
give an example.
GABA-A receptor agonists
- Ambien
what suppresses the sympathetic NS?
beta-blockers
beta-adrenergic receptor antagonists
