Ante/PeriNatology (OB/MFM vibes)

Question 1

4 mechanisms of placental drug transfer and some examples of each?

(December 2021)

Answer 1

-simple diffusion: most drugs, small, lipophilic
-facilitate diffusion: Glucocorticoids ie BMZ, cephalosporins
-active transport
-pinocytosis

Question 2

Antenatal steroids
-effect between 24-34 weeks?
-effect after 34 weeks?

(January 2022)

Answer 2

-decreased risk of IVH and RDS, reduces perinatal mortality. Recommended in this time range if at high risk for delivery within 7 days

-controversial. But decreases need for respiratory support in first 3 days of life but not in the rate of NICU admit. A/w increased risk of neonatal hypoglycemia and unknown effects on long-term neurodevelopment