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ANS pharm spreadsheet Flashcards

1
Q

Cholinergic (PNS) Agonists

Example of drugs

A

Pilocarpine-Bethanechol [M]
Neostigmine-Pyridostigmine (i)
Edrophonium-Donepezil (i)
Organophosphate nerve gases (i)

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2
Q

Cholinergic (PNS) Agonists

Effect on heart

A 
M = decr heart rate (SA node)
M = decr contractility (atria only)
M = decr conduction (AV node)
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3
Q

Cholinergic (PNS) Agonists

Effect on blood vessel

A

M = (vasodilation) [not innerv]

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4
Q

Cholinergic (PNS) Agonists

Effect on Blood pressure

A

M = decr blood pressure (danger= hypotension)

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5
Q

Cholinergic (PNS) Agonists

Effect on lung

A

M = bronchoconstriction (incr secretions)

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6
Q

Cholinergic (PNS) Agonists

Effect on eye

A 
M = miosis (constriction)
M = accomodation (near vision)
M = incr aqueous humor outflow (glaucoma)
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7
Q

Cholinergic (PNS) Agonists

Effect on GI/GU

A 
M = incr salivation (xerostomia)
M = incr detrusor contraction (incr urinary flow)
M = incr motility (paralytic ileus) (danger = diarrhea)
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8
Q

Cholinergic (PNS) Agonists

Effect on NMJ

A

NM = muscle contraction (myasthenia gravis)

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9
Q

Cholinergic (PNS) Agonists

Effect on CNS

A

M = memory/cognition/movement (alzheimer’s disease)

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10
Q

Cholinergic Antagonists (SNS)

Example of drugs

A

Atropine-scopolamine-benztropine [M]
Oxybutynin-Tolterodine [M]
Ipratropium-Tiotropium [M]
Atracurium-Rocuronium-Succinylcholine [Nm]

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11
Q

Cholinergic AntAgonists (SNS)

Effect on heart

A

incr heart rate [used in bradycardia]

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12
Q

Cholinergic AntAgonists (SNS)

Effect on blood vessels

A

no cholinergic tone to antagonize

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13
Q

Cholinergic AntAgonists (SNS)

Effect on blood pressure

A

minimal

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14
Q

Cholinergic AntAgonists (SNS)

Effect on lung

A

bronchodilation [asthma] can cause drying

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15
Q

Cholinergic AntAgonists (SNS)

Effect on eyes

A

mydriasis [eye exams]
can cause blurred vision
decr outflow (incr intraocular pressure) exacerbate glaucoma

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16
Q

Cholinergic AntAgonists (SNS)

Effect on GI/GU

A

decr salivation [creates dry field] (can cause dry mouth)
block detrusor [overactive bladder] (can cause urinary retention)
decr GI motility [diarrhea] (can cause constipation)

17
Q

Cholinergic AntAgonists (SNS)

Effect on NMJ

A

Flaccid paralysis [used ins surgery-muscle relax]

18
Q

Cholinergic AntAgonists (SNS)

Effect on CNS

A

[Parkinson’s disease/Anti-emetic] can cause sedation/confusion

19
Q

Adrenergic (SNS) agonists

Example of drugs

A 
epinephrine [a1-b1-b2]
norepinephrine [a-b1]
isoprorterenol [b1-b2]
albuterol [b2]
phenylephrine [a1]
pseudoephedrine (i)
dobutamine [b1]
dopamine [d1] (i)
20
Q

Adrenergic (SNS) agonists

effect on heart

A 
b1= incr heart rate/contractility [cardiogenic shock]
b1 = side effect of pro-arrhythmic, precipitate angina
21
Q

Adrenergic (SNS) agonists

effect on blood vessels

A 
a1 = vasoconstriction [hypotensive shock, decongestion] can cause hypertension
b2 = vasodilation
22
Q

Adrenergic (SNS) agonists

effect on blood pressure

A

a1, b1 = incr blood pressure [hypotensive shock]

b2 = decr blood pressure (if unopposed by a1)

23
Q

Adrenergic (SNS) agonists

effect on lung

A

b2 = bronchodilation [asthma]

24
Q

Adrenergic (SNS) agonists

effect on eye

A

a1 = mydriasis [eye exams]

b = incr humor production

25
Q

Adrenergic (SNS) agonists

effect on GIGU

A

a2 = GI relaxation [via decr ACh release]
B2-3 smooth muscle relaxation (bladder)

a1 = close sphincter [promote continence]
b2 = uterine relaxation [premature labor]
26
Q

Adrenergic (SNS) agonists

effect on NMJ

A

b2 = side effect of muscle tremors

27
Q

Adrenergic (SNS) agonists

effect on CNS

A

incr vigilance and focus

[ADHD]

28
Q

Adrenergic (PNS) antagonists

example of drugs

A 
prazosin-doxasozin-terazosin [a1]
metoprolol-atenolol [b1]
propranolol [b1-b2]
labetalol-caredilol [a1-b1-b2]
clonidine [a2 agonist]
29
Q

Adrenergic (PNS) antagonists

effect on heart

A 
b1 = decr HR, contractility [HTN/angina/arrhythmias/CHF]
b1 = side effect of bradycardia, heart block
30
Q

Adrenergic (PNS) antagonists

effect on blood vessels

A 
a1 = vasodilation [hypertension]
b2 = side effect of vasoconstriction, decr perfusion
31
Q

Adrenergic (PNS) antagonists

effect on blood pressure

A

a1, b1 = decr BP [HTN]
a2 agonist = decr BP [HTN]
via central effect at vasomotor center

side effect of dry mouth, sedation

32
Q

Adrenergic (PNS) antagonists

effect on lung

A

b2 = bronchospasm

33
Q

Adrenergic (PNS) antagonists

effect on eye

A

b1-2 decr aqueous humor production –> decr IOP [glaucoma]

34
Q

Adrenergic (PNS) antagonists

effect on GI/GU

A

a1 = open sphincter (ease voiding) [micturition disorders, BPH]

35
Q

Adrenergic (PNS) antagonists

effect on CNS

A

beta = [stage fright, essential tremor]

side effect of decr mood-sleep disturbance

Neuro_Week1 (26 decks)

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