ANS Part 3: adrenergic antag

Question 1

Phenoxybenzamine classification

Answer 1

irreversible non-selective alpha antagonist

Question 2

phenoxybenzamine binding to alpha 1 causes

Answer 2

vasodilation and lower BP

Question 3

phenoxybenzamine binding to alpha 2 causes

Answer 3

increase insulin

Question 4

phenoxybenzamine is used to treat

Answer 4

pheochromocytoma

Question 5

phentolamine classification

Answer 5

reversible non-selective alpha antagonist

Question 6

phentolamine binding to alpha 1 cuases

Answer 6

vasodilation and lower BP

Question 7

phentolamine binding to alpha 2 causes

Answer 7

increase NE

Question 8

phentolamine is used to treat

Answer 8

1. pheochromocytoma

2. hypertension

Question 9

prazosin classification

Answer 9

reversible alpha 1 antagonist

Question 10

what is prazosin used to treat

Answer 10

mild to moderate hypertension

Question 11

tamsulosin (Flomax) classification

Answer 11

reversible alpha 1a/1d antagonist

Question 12

tamsulosin effect

Answer 12

increase urine flow

Question 13

what is tamsulosin used to treat

Answer 13

benign prostate hyperplasia

Question 14

yohimbine classification

Answer 14

reversible alpha 2 antagonist

Question 15

low doses of yohimbine causes

Answer 15

• binding to alpha 2

- CNS excitation

Question 16

high doses of yohimbine causes

Answer 16

• binding to alpha 1

- vasodilation

Question 17

what is yohimbine used to treat

Answer 17

erectile dysfunction

Question 18

propanolol classification

Answer 18

non-selective beta antagonist

Question 19

propanolol binding to beta 1 causes

Answer 19

• decreaase BP

- decrease chrono/ino

Question 20

propanolol binding to beta 2 causes

Answer 20

• bronchoconstriction

- decreased insulin secretion

Question 21

what is propanolol ussed to treat

Answer 21

1. hypertension
2. heart arrhythmia
3. angina pectoris
4. myocardial infarction
5. prev. migraines

Question 22

bisoprolol classification

Answer 22

reversible B1 antagonist

Question 23

what does bisoprolol do

Answer 23

• decrease BP

- decrease chrono/ino

Question 24

what is bisoprolol used to treat

Answer 24

1. hypertension
2. heart arythmia
3. angina pectoris

Question 25

atenolol classification

Answer 25

reversible B1 antagonist

Question 26

what does atenolol do

Answer 26

- decrease BP | - decrease chrono/ino

Question 27

what is atenolol used to treat

Answer 27

1. hypertension 2. heart arythmia 3. angina pectoris

Question 28

betaxolol classification

Answer 28

reversible B1 antagonist

Question 29

what does betaxolol treat

Answer 29

glaucomoa

Question 30

pindolol classification

Answer 30

partial B1 agonist

Question 31

what does pindolol do

Answer 31

weakly increase BP and hypertension

Question 32

acebutolol classification

Answer 32

partial B1 agonist

Question 33

what does acebutolol do

Answer 33

weakly increase BP and hypertension

Question 34

carvedilol classification

Answer 34

mixed alpha1/beta antagonist

Question 35

why is it hard to track conc of an irreversible drug

Answer 35

because the plasma conc of the drug is not accurate of tissue conc of drug

Question 36

recovery of an irreversible drug requires

Answer 36

synthesis de novo of new receptors!

Question 37

AEs of phenoxybenzamine

Answer 37

- postural hypotension - reflex tachycardia - arrhythmia - MI

Question 38

AEs of phentolamine

Answer 38

postural hypotension

Question 39

if you have glaucoma, you should not take this drug

Answer 39

phenylephrine

Question 40

clonidine is reversed by which drug

Answer 40

yohimbine

Question 41

why should you not give someone who has asthma or copd propranolol to treat their hypertension

Answer 41

because it will also target beta 2 => bronchoconstriction => trouble breathing

Question 42

what is the drug of choice for patients with CAD and HF

Answer 42

bisoprolol

Question 43

why should you not give someone who has type 2 diabetes propranolol to treat their hypertension

Answer 43

because propanolol decreases insulin secretion

Question 44

which has a longer half life? atenolol or bisoprolol

Answer 44

bisoprolol