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Pharmacology > ANS Part 3: adrenergic antag > Flashcards

ANS Part 3: adrenergic antag Flashcards

1
Q

Phenoxybenzamine classification

A

irreversible non-selective alpha antagonist

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2
Q

phenoxybenzamine binding to alpha 1 causes

A

vasodilation and lower BP

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3
Q

phenoxybenzamine binding to alpha 2 causes

A

increase insulin

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4
Q

phenoxybenzamine is used to treat

A

pheochromocytoma

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5
Q

phentolamine classification

A

reversible non-selective alpha antagonist

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6
Q

phentolamine binding to alpha 1 cuases

A

vasodilation and lower BP

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7
Q

phentolamine binding to alpha 2 causes

A

increase NE

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8
Q

phentolamine is used to treat

A
  1. pheochromocytoma

2. hypertension

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9
Q

prazosin classification

A

reversible alpha 1 antagonist

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10
Q

what is prazosin used to treat

A

mild to moderate hypertension

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11
Q

tamsulosin (Flomax) classification

A

reversible alpha 1a/1d antagonist

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12
Q

tamsulosin effect

A

increase urine flow

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13
Q

what is tamsulosin used to treat

A

benign prostate hyperplasia

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14
Q

yohimbine classification

A

reversible alpha 2 antagonist

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15
Q

low doses of yohimbine causes

A
  • binding to alpha 2

- CNS excitation

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16
Q

high doses of yohimbine causes

A
  • binding to alpha 1

- vasodilation

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17
Q

what is yohimbine used to treat

A

erectile dysfunction

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18
Q

propanolol classification

A

non-selective beta antagonist

19
Q

propanolol binding to beta 1 causes

A
  • decreaase BP

- decrease chrono/ino

20
Q

propanolol binding to beta 2 causes

A
  • bronchoconstriction

- decreased insulin secretion

21
Q

what is propanolol ussed to treat

A
  1. hypertension
  2. heart arrhythmia
  3. angina pectoris
  4. myocardial infarction
  5. prev. migraines
22
Q

bisoprolol classification

A

reversible B1 antagonist

23
Q

what does bisoprolol do

A
  • decrease BP

- decrease chrono/ino

24
Q

what is bisoprolol used to treat

A
  1. hypertension
  2. heart arythmia
  3. angina pectoris
25
Q

atenolol classification

A

reversible B1 antagonist

26
Q

what does atenolol do

A
  • decrease BP

- decrease chrono/ino

27
Q

what is atenolol used to treat

A
  1. hypertension
  2. heart arythmia
  3. angina pectoris
28
Q

betaxolol classification

A

reversible B1 antagonist

29
Q

what does betaxolol treat

A

glaucomoa

30
Q

pindolol classification

A

partial B1 agonist

31
Q

what does pindolol do

A

weakly increase BP and hypertension

32
Q

acebutolol classification

A

partial B1 agonist

33
Q

what does acebutolol do

A

weakly increase BP and hypertension

34
Q

carvedilol classification

A

mixed alpha1/beta antagonist

35
Q

why is it hard to track conc of an irreversible drug

A

because the plasma conc of the drug is not accurate of tissue conc of drug

36
Q

recovery of an irreversible drug requires

A

synthesis de novo of new receptors!

37
Q

AEs of phenoxybenzamine

A
  • postural hypotension
  • reflex tachycardia
  • arrhythmia
  • MI
38
Q

AEs of phentolamine

A

postural hypotension

39
Q

if you have glaucoma, you should not take this drug

A

phenylephrine

40
Q

clonidine is reversed by which drug

A

yohimbine

41
Q

why should you not give someone who has asthma or copd propranolol to treat their hypertension

A

because it will also target beta 2 => bronchoconstriction => trouble breathing

42
Q

what is the drug of choice for patients with CAD and HF

A

bisoprolol

43
Q

why should you not give someone who has type 2 diabetes propranolol to treat their hypertension

A

because propanolol decreases insulin secretion

44
Q

which has a longer half life? atenolol or bisoprolol

A

bisoprolol

Pharmacology (17 decks)

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