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Pharmacology > ANS 3 > Flashcards

ANS 3 Flashcards

1
Q

Tyrosine Hydroxylase is inhibited by this substrate and is also the rate limiting step

A

Norepinephrine

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2
Q

A non-specific enzyme not confined to catecholamine synthesising cells

A

Dopa decarboxylase

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3
Q

A non-specific enzyme but is restricted to catecholamine synthesizing cells

A

Dopamine B-Hydroxylase

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4
Q

Main location is in the adrenal medulla and production is induced by a steroid hormone

A

Phenylethanolamine N-methyltransferase (PNMT)

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5
Q

Major factor that controls the rate of synthesis of epinephrine by increasing PNMT

A

Glucocorticoid

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6
Q

Storage of NE is contained in?

A

Vesicles

Maintained by VMAT

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7
Q

75% of NE is recaptured and repackaged mediated by?

A

Norepinephrine Transporter (NET)

25% by EMT

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8
Q

This enzyme degrades NE and is found in Mitochondria and abundant in Noradrenergic nerve terminals

A

Monoamine oxidase (MAO)

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9
Q

Degrades NE but absent in Noradrenergic nerve terminals but present in adrenal medulla

A

Catechol-O-Methyltransferase (COMT)

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10
Q

End product NE metabolism

A

Vanillylmandelic acid (VMA)

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11
Q

Synapse where the 2nd messenger is cAMP?

A

Presynaptic adrenergic receptors

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12
Q

Type of receptors found in the presynaptic membrane

A

a2, B2

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13
Q

Postsynaptic receptor where the 2nd messenger is phospholipase C?

A

a1

The rest is cAMP mediated

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14
Q

What type of presynaptic receptor decreases cAMP when activated?

A

a2

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15
Q

Main neurotransmitter found in postganglionic sympathetic fiber?

A

Norepinephrine

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16
Q

Main catecholamine secreted by the adrenal medulla?

A

Epinephrine

17
Q

NT in the CNS?

A

Dopamine

18
Q
  • Can pass the BBB
  • CNS stimulant action
  • Longer Duration (COMT resistant)
A

Non-Cathecolamine

19
Q

Direct acting Adrenergic agonist

A 
Norepinephrine 
Epinephrine 
Isoproterenol 
Phenylephrine
Dobutamine
Terbutaline

(DirectT EPIN)

20
Q

Rank of order for a1 potency

A

Epinephrine≥ Norepinephrine» Isoproterenol

21
Q

Effects of NE stimulation to a1

A

Vasoconstriction (also for a2)
Pupil Dilation
Ejaculation

22
Q

Effects of NE stimulation to a2

A

Decrease activation of cAMP
Inhibits release of NE and Ach
Decreases aqueous humor
Low insulin

23
Q

Activation of B1

A

Heart: Inc Contraction, Inc HR
Kidney: Renin Release = Angiotensin

(Contraction)

24
Q

Rank of order of potency for B1

A

Isoproterenol > Epinephrine ≥ Norepinephrine

25
Q

Receptors which also activates adenylyl cyclase leading to inc cAMP but inactivates MLCK having relaxation

A

B2

Bronchodilation, Uterine Relaxation, Inc Metabolic effects

26
Q

Rank of order of potency for B2

A

Isoproterenol > Epinephrine&raquo_space; Norepinephrine

27
Q

Has (+++) activity for A1 and B1

A

Norepinephrine

28
Q

A non-catecholamine which has (+++) for A1, B1 and B2

A

Ephedrine

29
Q

Has minimal activity for B2

A

Norepinephrine

30
Q

(+++) activity for a2

A

Clonidine

31
Q

Action of B3 stimulation

A

Increase Lipolysis

32
Q

Inhibits secretion of aqueous humor

A

a2

B inc secretion of aqueous humor

33
Q

Acidic urine enhances its excretion

A

Ephedrine

34
Q

Has higher central than peripheral effects than Amphetamine and CNS actions is attributed by release of Dopamine and Norepinephrine

A

Metamphetamine

35
Q

Proven efficacy in children with Attention deficit hyperactivity disorder (ADHD)

A

Methylphenidate

36
Q

Used as nasal decongestant and appetite suppresant

A

Phenylpropanolamine

Adverse Effect: Stroke

37
Q

High concentrations in fermented food which causes to release stored catecholamines

A

Tyramine

Pharmacology (8 decks)

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