Animals Models

Question 1

Endogenous source of cholesterol

Answer 1

Acetyl-CoA makes cholesterol
Acegtyk-CoA -> HMG-CoA -> mevalonate ( enzyme Hmagcr is used) important enzyme to make cholesterol

This pathways is related to the pathway of cholesterol synthesis it will make geranylgeranyl PP which is important for cellular metabolism. Without this the cells will die

Statins is a drug that interfere with the enzyme HMGCR - this drug is used when you have a lot of cholesterol so it will decrease cholesterol

Question 2

Cholesteryl esters

Answer 2

Our body controls the amount of free cholesterol that we have in our body. If it passes the threshold it will estérified
The cholesterol

Question 3

Processing of diet derived lipids

Answer 3

The bile acid and the bile salt are going to emulsify the lipids. It will make them interact with water and that way lipase can breaks down. The smaller molecules will entre the cell and after they are going to get together

Question 4

What is the transporter for cholesterol to enter the cell

Answer 4

NPC1L1

Question 5

What are the major lipids in CM, VLDL,IDL, LDL, HDL

Answer 5

CM and VLDL triacylglycerol
IDL AND LDL cholesteryl esters
HDL phospholipids

Question 6

Functions of the alipoprotein

Answer 6

APO A1 : structure of CM and HDL and LCAT activitor

APO B-48: structure chylomicrons

APO B100: structure VLDL,LDLR ligand