Anemia Part 2

Question 1

Characterized by premature RBC destruction caused by
autoantibodies that bind the RBC surface

Answer 1

Autoimmune hemolytic anemia (AHA)

Question 2

The most common, and the antibody that is present here
is the IgG (bind) to RBC membrane that will cause an
extravascular hemolysis and Splenomegaly
(enlargement of the spleen)

Answer 2

Warm reactive Autoimmune hemolytic anemia

Question 3

Two causes warm reactive autoimmune hemolytic anemia

Answer 3

Primary 1= idiopathic
Secondary 2= infection, malignancy lymphoma, medication, viral infection

Question 4

Shape of warm reactive autoimmune hemolytic anemia

Answer 4

Spherocytes

Question 5

Warm reactive autoimmune hemolytic anemia Mediated by antibody with maximum binding affinity at

Answer 5

37C

Question 6

Cold-reactive autoimmune hemolytic anemia Mediated by antibody with maximum binding affinity at

Answer 6

4C or below 32C

Question 7

the antibody that is present here is the IgM (bind) to
RBC membrane that will cause complement activation
so the hemolysis that will occur is intravascular

Answer 7

Cold reactive autoimmune hemolytic anemia

Question 8

Two causes of cold reactive autoimmune hemolytic anemia

Answer 8

Primary 1* = idiopathic and more on elderly
Secondary 2*= infection

Question 9

A rare acute form of cold-generated hemolysis, common
sa children

Answer 9

Paroxysmal cold hemoglobinuria

Question 10

Paroxysmal cold Hemoglobinuria Caused by antibody

Answer 10

Donath landsteiner antibody

Question 11

Type of hemolysis: warm-reactive

Answer 11

Extra vascular

Question 12

Type of hemolysis: cold reactive

Answer 12

Intra/extravascular

Question 13

Type of hemolysis paroxysmal cold hemoglobinuria

Answer 13

Intravascular

Question 14

Treatment warm reactive:

Answer 14

Corticosteriod splenectomy

Question 15

Treatment cold reactive:

Answer 15

Avoidance of Cold plasmapheresis