Andersen: Junctions Flashcards
1
Q
Binding between cadherins is generally
A
Homophillic
2
Q
Calcium role in cadherins
A
Calcium ions bind to hinge sites connecting cadherin domains in extracellular surface. This strengthens the site and keeps it from bending. When calcium is removed, the cadherin structure becomes floppy and degrades
3
Q
Cadherin and cell sorting
A
Cadherin-dependent homophilic interactions mediate highly selective recognition, enabling cells of a similar type to stick together and stay segregated from other cell types
4
Q
Catenins
A
Small proteins that link cytoplasmic end of cadherin with cytoplasmic actin
5
Q
Conserved polarity proteins
A
Par
Crumbs
Scribble
