Anatomy and Imaging Flashcards
Skeletal muscle in the GI tract is found in the (4)
mouth
pharynx
upper oeso
external anal sphincter
4 activities of the GI tract =
motility (mainly SM)
secretion
digestion
absorption
contains epithelial, exocrine and endocrine gland cells
lamina propria
muscularis mucosae
GI mucosa
4 layers of GI tract wall =
mucosa > submucosa > musularis externa > serosa
Regulates the SA and shape of mucosa layer in gut
muscularis mucosae
Lamina propria of gut wall contains:
capillaries
enteric NS
immune cells
made up of connective tissue, blood and lymph vessels, glands and nerve network
submucosa
regulates the absorptive and secretive functions of the submucosa
Meissner’s/submucosal plexus
___ muscle then _____ plexus (regulates mechanical activity of the gut) then ____ muscle
In typical gut wall muscularis externa
circular
Myenteric/Auerbach’s
longitudinal
Connective tissue layer of gut wall that secretes sticky fluid so gut slides over itself
serosa
Contraction of gut circular muscle causes ___
tube to narrow and lengthen
Contraction of gut longitudinal muscle causes ____
tube to shorten and fatten
3 bands of muscularis externa longitudinal muscle in colon
teniae coli
Slow wave electrical activity in the enteric NS is driven by ____
ICC pacemakers
Interstitial cells of Cajal
ICCs lie in :
between muscle layers of muscularis externa
in submucosa
few in SM cells
___ allow depolarisation and contraction in the gut to occur as a functional syncytium
gap junctions => single unit SM
Upstroke of slow wave electrical activity in the gut is caused by ___
voltage activated Ca2+ channels = Ca2+ influx
Downstroke of slow wave electrical activity in the gut is caused by ____
voltage and Ca2+ activated K+ channels = K+ efflux
ICC are regulated by ,+_
enteric+autonomic nerves
hormones
The force of gut contraction is directly proportional to the ___ from ICC
number of APs produced
Determines the max. frequency, direction and velocity of gut contractions
Slow wave electrical activity - driven by ICCs
BER (basic electrical rhythm) is determined by:
slow wave electrical activity
BER in duodenum is greater/less than in ileum = food moves in ___ direction
greater
aboral
BER in proximal colon is greater/less than in the sigmoid colon = food moves in ___ direction
less
oral
neuronal, hormonal and mechanical stimuli increase the chance of slow waves getting to threshold by ____
increasing basal depolarisation by opening Ca2+ L channels
Plexus in gut that modulates epithelia and blood vessels=
Meissner’s/submucosal
Plexus in gut that regulates motility and sphincters =
Myenteric/Auerbach’s
Key transmitters in enteric NS =
ACh, substance P, NO + VIP - regulate peristalsis
5-HT
sensory neurones in the gut are __,_+___ receptors
thermo, chemo and mechano
Most abundant type of neuron in enteric NS
co-ordinate reflexes and motor programs
interneurones
motor neurones in the enteric NS supply the (4)
SM, secretory epithelium, endocrine glands + blood vessels
Vagus nerve supplies ___(4) in the gut with parasympathetics
oesophagus stomach small intestine ascending colon (synapses with ENS)
Supplies the descending and sigmoid colon with parasympathetics
pelvic nerves
S2-4 (synapses with ENS)
Excitatory effects of parasympathetics on GI tract (3)
Increase gastric, pancreatic and small int secretions
increase blood flow to gut
increase SM contraction
Inhibitory effects of parasympathetics on GI tract
relax some sphincters and the stomach
Pre/postganglionic autonomic fibres synapse with ENS
answer for para and symp
para = pre symp = post (synapses first in superior cervical and prevertebral - celiac aand sup inf mesenteric - ganglia)
excitatory effects of sympathetics on GI tract
increase sphincter tone
inhibitory effects of sympathetics on GI tract
decrease motility, secretions and blood flow
Example of a local reflex in the GI tract
peristalsis
In local and short reflexes in the GI tract the sensory, inter and effector neurones are found in the
myenteric plexus in the muscularis externa
Example of a short reflex in the GI tract
intestino-intestinal inhibitory reflex
What happens in the intestino-intestinal inhibitory reflex?
local distension > (sensory neurone) > sympathetic pre-ganglion > (interneurone) > (effector neurone) > decreased muscle activity in adjacent areas
Example of a long reflex in the GI tract
gastroileal
What happens in the gastro-ileal reflex?
increased gastric activity > increased propulsion in terminal ileum
…> sensory neurone (outwith muscularis externa) > dorsal motor nucleus (of vagus in medulla oblongata) > interneurone > effector neurone > …
occurs in which reflex?
Long reflex in GI tract eg. gastroileal
__+___ causes muscle layers in the gut to contract in peristalsis
ACh and substance P
__+___ cause muscle layers in the gut to relax in peristalsis
NO and VIP
In the gut segment in front of food in peristalsis
longitudinal SM ___ and circular SM ___
In front =
longitudinal contracts
circular relaxes
In the gut segment behind food in peristalsis
longitudinal SM ___ and circular SM ___
Behind =
longitudinal relaxes
circular contracts
Rhythmic circular contraction in the small intestine = function = occur in \_\_ state
segmentation
mixes food
fed state
rhythmic circular contraction in large intestine that mixes food =
haustration
powerful contraction that moves faeces into the rectum and occurs a couple x per day
colonic mass movement
causes a powerful contraction to move food from the stomach to the terminal ileum
MMC - migrating motor complex
tonic contractions occur in organs with ___ function
eg. ___+___ = __ pressure
and in sphincters = ___ pressure
storage = gallbladder and stomach = low P sphincters = high P
Two skeletal sphincters in GI tract
UOS and external anal
Pressure upstream/downstream of a sphincter ___ it
up = opens down = shuts
UOS relaxes in ___
closes in ___
open = swallowing closes = inspiration
LOS relaxes in ___
closes in ___
open in food>stomach
closes to prevent reflux
Pyloric sphincter regulates ___ and prevents ___
gastric emptying
prevents duodenal reflux
Muscle(s) that opens the mouth
lateral pterygoid
muscle(s) that close the mouth
medial pterygoid, masseter and temporalis
deglutition =
swallowing
1st/Voluntary/___ phase of deglutition:
___ receptors are stimulated when bolus reaches oropharynx
> afferents via ____ > __+___ > efferents ___ >
oral mechanoreceptors CN IX and X pons and medulla CN 7, 9, 10, 11 skeletal muscles of pharynx and larynx
2nd/pharyngeal phase of deglutition:
soft palate ___ and post. pharynx wall ___ to separate naso and oropharynx
ventilation is ___
___ muscles close the glottis and raise the ___
Sup. and middle pharyngeal ____
bolus moves ___ enters ___
soft palate rises post. pharynx wall constricts vent = inhibited laryngeal muscles raise larynx pharyngeal constrictors constrict epiglottis -> oesopahgus ventilation resumes
3rd/Oesophageal phase of deglutition lasts -
4-10 seconds
3rd/Oeso phase of deglutition:
___+___ > CNX -> ____ + ____
pons and medulla
close UOS and cause primary peristaltic wave
If bolus is lodged in oesophagus ____ receptors cause ___ and increased ___
local pressure receptors =
2ndry more powerful peristaltic wave and increased saliva production
Parotid gland lies:
anterior to ear and below zygomatic arch
The parotid duct/ _____ enters the mouth opposite the ____
duct of Stensen
2nd maxillary molar teeth
Parotid gland makes up ___% of salivary production
25%
Parotid gland is innervated by ___
CN IX and sympathetic plexus
___ cells in the Parotid gland secrete and ___ solution
serous cells =
watery α-amylase rich
Submandibular salivary glands lie ___
medial to body of the mandible
the submandibular salivary duct/____ enters mouth via the ___ at ____
duct of Wharten
via sublingual caruncula at the lingual frenulum (under tongue)
Submandibular glands make up __% of saliva secretion
70%
Submandibular glands have ___ cells
There secretion is more/less viscous than parotids
mucous and serous cells
more
Submandibular salivary glands are innervated by :
CN 7 and sympathetic plexus
Sublingual salivary glands lie ___
medial to submandibular glands
Sublingual salivary duct/___ -> ___ duct and connects with duct of Wharten at the ___
ductus of Rivinus
common Bartholin
sublingual caruncula
Sublingual glands make up __% of saliva secretions
5%
Sublingual glands have ___ cells = a ___ solution
mucous
mucus rich solution
Sublingual glands are innervated by ___
CN 7
Salivary glands are complex endo/exocrine glands.
Have an external ___
fibrous ___ between lobes and lobules
lobules are composed of ___
EXOcrine
external CAPSULE
fibrous SEPTA
lobules composed of SALIVONS
3 main parts of a salivon =
secretory acinus
intercalated duct
striated duct
Basic structure of secretory acinus in salivon
pyramiddal acinar cells around a central lumen
Serous acinar cells in salivons secrete ___ from ___ secretory granules
watery α-amylase rich secretion
small dense
Mucous acinar cells in salivons secrete ___ from ___ granules
mucus
large, pale
Serous and mucous acinar cells in salivons are surrounded by ___ which ___
myoepithelial cells
squeeze saliva into ducts
_____ at terminal end of secretory acinus in salivons secrete lysozymes
Serous demilunes
Intercalated ducts in salivons are made of ___ epithelium
cuboidal
Striated ducts in salivons are ___ epithelium with lots of ___ for active transport to modify saliva
combine to form __ and then ___
columnar epithelium with lots of mitochondria
interlobular > excretory ducts
attachments of the masseter muscle
closes mouth
angle of mandible
zygomatic arch
attachments of the temporalis muscle
closes mouth
coronoid process of mandible
temporal fossa
attachments of the medial pterygoid
closes mouth
medial side angle of mandible
pterygoid plates of the sphenoid
attachments of the lateral pterygoid
opens mouth
condyle of mandible
pterygoid plates of the sphenoid
the muscles that open and close the mouth are supplied by ____ nerve
mandibular CNV division
CNV3
course of CNV3
attaches to pons -> inferior edge of ____ between post.+middle ____ > ____ in sphenoid bone > structures
pons >
tentorium cerebelli ; cranial fossa >
foramen ovale
provides sensation to anterior 2/3 of tongue
special and general
general = CNV3 special = CNVII
provides sensation to posterior 1/3 of tongue
special and general
general and special = CNIX
Provides sensation to the superior 1/2 of oral cavity
gingivae and palate
general = CNV2
Vert2go - vertigo=high part
Provides sensation to the inferior 1/2 of oral cavity
gingivae and floor
general = CNV3
sensory nerves of gag reflex =
respond to ___
CNIX
touch to posterior wall of oral cavity
motor nerves of gag reflex =
cause ___
CNIX and X
pharynx to constrict
in endoscopy local anaesthetic spray blocks nerves:
CN V2, V3, VII, IX
5, 7, 9