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A Intro to Neuro > Anatomy 1 > Flashcards

Anatomy 1 Flashcards

1
Q

What is decussation?

A
  • Axons crossing the midline
  • Important example: The corpus callosum is the major fiber tract connecting the L & R hemispheres of the brain.
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2
Q

Lateral vs. medial

A
  • Lateral = away from midline
  • Medial = towards midline
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3
Q

Contralateral

A

Opposite side of body or brain as another structure

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4
Q

Ipsilateral

A

Same side of body or brain as another structure

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5
Q

Directional terms with mouse

A
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6
Q

Rostral

A

Sounds like nostril!

Towards the nose/front in a quadruped

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7
Q

Dorsal

A

Towards back (dos in French)

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8
Q

Directional terms & neuraxis

A
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9
Q

Directional terms ending with -ior vs. -al

A
  • Ends with -ior: Directions are perpendicular or parallel to the ground
  • Ends with -al: Directions are relative to the neuraxis
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10
Q

Planes of section

A
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11
Q

Transverse sections

A

Starts coronal rostrally –> becomes horizontal caudally

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12
Q

Transverse sections are always ___ to the neuraxis

A

Perpendicular

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13
Q

Examples of directional terms (separate into flashcards)

A
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14
Q

White vs. grey matter

A
  • White matter is mostly axons
  • Grey matter is mostly cell bodies
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15
Q

Afferent vs. efferent

A
  • Afferent fibers arrive into the central nervous system (ex. sensory axon
    carrying information from fingertips into the dorsal root of the spine).
  • Efferent fibers exit the central nervous system (ex. motor axon exiting the
    ventral root of the spine to control fingertips).
  • We will be using these terms to describes fibers as they arrive in or exit the
    central nervous system (brain and spine), but you will encounter these terms
    in the future to refer to specific regions (ex. afferent fibers arriving into the
    thalamus)
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16
Q

Divisions of the NS - flow chart

A
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17
Q

What does the central nervous system include?

A

Brain and spinal chord

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18
Q

What does the peripheral nervous system include?

A

Everything except the brain and spine, e.g. spine nerves

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19
Q

What are the two divisions of the peripheral NS?

A
  • Somatic (voluntary)
  • Visceral/autonomic (involunary)
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20
Q

Somatic nervous system

A
  • Voluntary
  • Motor axons control muscle contractions (soma in CNS vs. axons in PNS)
  • Sensory nerves entering spine containing info from skin, muscles, and joints
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21
Q

Visceral/autonomic nervous system

A
  • Involuntary
  • Innervates internal organs, blood vessels, and glands
  • Motor axons control relaxation or contraction of walls of blood vessels and intestines i.e. smooth muscles
  • Sensory axons carry info on visceral function (e.g. pressure in blood vessels)
  • Divided into sympathetic (fight or flight) and parasympathetic (rest and digest)
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22
Q

Diagram of spinal cord

A
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23
Q

Components of spinal nerve (look at pink box in diagram)

A
  • Afferent dorsal root (going into spine)
  • Efferent ventral root (going out of spine)
  • There is one spinal nerve for each level of the spinal cord
  • The dorsal root ganglia contain the cell bodies of sensory neurons BUT there are no ventral root ganglia
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24
Q

How many spinal nerves are there for each level of the spinal cord?

A

1

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25
Q

Dorsal root ganglia

A
  • Contain the cell bodies of sensory neurons
  • No ventral root ganglia
26
Q

Meninges (look at blue box)

A
  • Also cover spinal cord and follow same order as spinal (outermost to innermost): Dura mater, subdural space, arachnoid, subarachnoid space, membrane, pia mater
27
Q

Cross-section of spinal cord

A
  • Gray matter (middle) can be divided into dorsal horn, intermediate zone, or ventral horn
  • White matter (outside) can be divided into dorsal column (pink), lateral column (blue), or ventral column (purple)
28
Q

Diagram of meninges

A
29
Q

What are the three meninges?

A
  • Dura mater
  • Arachnoid membrane
  • Pia mater
30
Q

The CNS is protected by the ___, a layer of _ membranes

A

Menings, 3

31
Q

Dura mater

A

Outermost and leather-like layer

32
Q

Subdural space

A

Between dura mater and arachnoid membrane

33
Q

What causes a subdural hematoma?

A

When blood vessels passing through the dura burst

34
Q

Arachnoid membrane

A

Spider web-like meningeal layer

35
Q

Subarachnoid space

A
  • Between arachnoid and pia mater
  • Contains CSF (cerebro-spinal fluid)
  • Lies just under arachnoid membrane
36
Q

Pia mater

A
  • Thin, innermost membrane
  • Adheres closely to the surface of the brain
  • Many blood vessels run along this membrane
37
Q

Which is the thinnest layer of the meninges?

A

Pia mater

38
Q

Meningitis

A

Infection of meninges

39
Q

What are the three layers of the embryo?

A
  • Endoderm
  • Mesoderm
  • Ectoderm
40
Q

Endoderm of embryo

A
  • Innermost/ventral layer of cells
  • Develops into internal organ lining
41
Q

Mesoderm of embryo

A
  • Middle layer of cells
  • Develops into bones and muscle
42
Q

Ectoderm of embryo

A
  • Outermost layer of cells
  • Develops into nervous system and skin
43
Q

Neural plate

A

Portion of the ectoderm that develops into the nervous system

44
Q

What is the neural tube?

A

A tube that develops from an inward folding of the neural plate and is the actual precursor to the entire CNS

45
Q

What is neurulation?

A
  • The process that creates the neural tube
  • The actual conformational change of the neural plate into the neural tube
  • Occurs early in embryonic development (~22 days)
46
Q

Steps of neurulation/neural tube development

A
  1. The neural plate sinks/folds inward in a U-shape to form a groove (entire green structure in diagram)
  2. The lateral ends of the neural plate (purple structure) become the walls of the neural groove and are called the neural folds
  3. The two neural folds come together medially to fuse and form the neural crest, which also leads to the closing of the neural groove into the neural tube
47
Q

Development of PNS vs. CNS

A

Medial Neural Plate → Neural Groove → Neural Tube
→ CNS

Lateral Neural Plate → Neural Fold → Neural Crest →
PNS

48
Q

A failure to close the rostral end of the neural tube can cause ___

A

Anencephaly, lack of brain (fatal)

49
Q

Neuropore (neural tube defect)

A
  • Opening/gaps in the neural tube.
  • Failure to seal and close neuropores during embryonic development leads to neural tube
    defects that leave infants with undeveloped brains and spinal cords at
    birth
50
Q

Anencephaly (neural tube defect)

A
  • Neural tube defect that results from a failure to close the anterior/rostral end of the neural tube
  • Results in infants having incomplete brains and skulls
  • Incurable and leads to death shortly after birth
51
Q

Spina bifida

A
  • Neural tube defect that results from a failure to close the posterior/caudal end of the neural tube
  • Typically results in a sac of spinal fluid protruding from the mid to lower back that sometimes impairs ability to walk, damages bladder and bowel control, and causes hydrocephalus
  • Can be treated through surgery
52
Q

Anencephaly results from failure to close the ___ end of the neural tube

A

Anterior/rostral

53
Q

Spina bifida results from failure to close the ___ end of the neural tube

A

Posterior/caudal

54
Q

Neural tube differentiation

A
55
Q

Forebrain neural differentiation

A
56
Q

Midbrain differentiation

A
57
Q

Hindbrain differentiation

A
58
Q

Neurogenesis

A
  • BrdU substitutes for thymidine in DNA, so any cells dividing would pair BrdU instead of A-T pair
  • Post-mortem, neurons (not just glia or stem cells) showed up BrdU positive
59
Q

Where do neural stem cells exist?

A
  • Subventricular zone (SVZ): development
  • Dentate gyrus of hippocampus in temporal lobe of adults
  • Olfactory bulbs
  • Adult humans are still capable of growing a few new neurons in these selective neurons
60
Q

Ventricular system

A
  • The ventricular system is a series of connected fluid-filled chambers and canals called ventricles.
  • The fluid filling these chambers is cerebrospinal fluid (CSF).
61
Q

3rd vs. lateral ventricles

A
  • If the cross-section is more rostral, the 3rd ventricle will be absent or very small
  • Paired chambers are good evidence that the ventricles you are looking at are the lateral ventricles (general rule but not always the case)
  • If you ever see ventricle in the very lateral areas of the cortex (e.g. in the temporal lobe, bordering the hippocampus or amygdala, this is lateral ventricle due to its ram horn-like shape
62
Q

LLC - lateral ventricles

A

LLC = Lateral to the Lateral ventricle is the Caudate
- If the lateral ventricles and 3rd ventricle are both present in the same cross-section, the caudate will be lateral to the lateral ventricles vs. the thalamus will be lateral to the 3rd ventricle

A Intro to Neuro (7 decks)

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