Analgesics (Part 2) Flashcards
What drugs are under Selective COX-2 inhibition?
1: Carprofen
2: Deracoxib
3: Robenacoxib
4: Firocoxib
5: Meloxicam
6: Piroxicam
What drugs are under Non-selective COX-1 and COX-2 inhibition?
1: Phenylbutazone
2: Flunixin meglumine
What drug is under Selective COX-1 inhibition?
Aspirin (ASA)
What are the main effects of NSAID’s?
1: Prevent inflammation
2: Most commonly used analgesics
3: Potential adverse effects
What are the other uses for NSAID’s?
1: Anti-pyretic
2: Inhibition of tumor growth
True or False: NSAID’s and corticosteroids can be used together.
False
Describe COX-1
1: Constitutive, physiologic production of prostaglandins that play an important role in normal homeostasis
2: Thromboxane A2
3: Prostaglandin E1
Describe COX-2
Inducible production of prostaglandins produced during times of inflammation
What do anti-inflammatory drugs do?
Inhibit synthesis of eiconsanoids
Anti-inflammatory effects are _____.
Greater for acute inflammation than for chronic inflammatory conditons
What are the analgesic effects of NSAID’s?
1: COX selectivity does not necessarily relate to efficacy as analgesics
2: NASID’s provide analgesia wether inflammation is present or not, but are MOSR effective in the acute phase of injury
When is the best time to give NSAID’s?
Before or just after tissue injury occurs
What are antipyretic effect of NSAID’s?
Fever reduction
What are the possible anti-endotoxic effects of NSAID’s?
1: Experimentally beneficial if administered before endotoxemic challenge
2: It remains unclear how much clinical benefit is seen when administered after
What are the pharmacokinectics of NSAID’s?
1: Weak acids
2: Highly protein bound
3: Generally good absorption and bioavailability with PO or IM routes
4: Low volume of distribution
